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Effects of estrogen on lifespan and motor functions in female hSOD1 G93A transgenic mice.

Choi, CI; Lee, YD; Gwag, BJ; Cho, SI; Kim, SS; Suh-Kim, H
Journal of the neurological sciences, 268(1-2):40-47, 2008
Journal Title
Journal of the neurological sciences
Amyotrophic lateral sclerosis (ALS) is a progressive disease which is caused by degeneration of motor neurons in the central nervous system. The incidence of ALS is higher in men than women, but the female advantage disappears with increased age. Here, we report evidence that the female advantage is due to the protective role of estrogen. In an ALS mouse model carrying the human Cu/Zn superoxide dismutase (hSOD1) G93A transgene, ovariectomy did not alter the onset age of the disease while reducing the female lifespan by 7 days and making it comparable to that of the male transgenic mice. Treatment of ovariectomized females with 17beta-estradiol (E2) did not delay the onset of disease, but prevented progression of ALS motor dysfunctions as shown by extension reflex test for a limited time window. Importantly, E2 treatment rescued the lifespans in overiectomized females. These findings will provide important new insights to interpretation of disease progression in post-menopausal female ALS patients.
MeSH terms
Age of OnsetAmyotrophic Lateral Sclerosis*/drug therapyAmyotrophic Lateral Sclerosis*/mortalityAmyotrophic Lateral Sclerosis*/physiopathologyAnalysis of VarianceAnimalsDisease Models, AnimalEnzyme-Linked Immunosorbent Assay/methodsEstradiol/therapeutic use*Estrogens/therapeutic use*FemaleHumansMaleMiceMice, TransgenicMotor Activity/drug effects*Organ Size/drug effectsOvariectomy/methodsProbabilityPsychomotor Performance/drug effects*Reaction Time/drug effectsSex FactorsSuperoxide Dismutase/genetics*
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anatomy
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
Journal Papers > Research Organization > Research Institute for Neural Science & Technology
AJOU Authors
이, 영돈곽, 병주조, 성익김, 성수서, 해영
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