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Characterization of ionic currents in human neural stem cells.

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dc.contributor.authorLim, CG-
dc.contributor.authorKim, SS-
dc.contributor.authorSuh-Kim, H-
dc.contributor.authorLee, YD-
dc.contributor.authorAhn, SC-
dc.date.accessioned2011-01-14T06:28:28Z-
dc.date.available2011-01-14T06:28:28Z-
dc.date.issued2008-
dc.identifier.issn1226-4512-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/1160-
dc.description.abstractThe profile of membrane currents was investigated in differentiated neuronal cells derived from human neural stem cells (hNSCs) that were obtained from aborted fetal cortex. Whole-cell voltage clamp recording revealed at least 4 different currents: a tetrodotoxin (TTX)-sensitive Na(+) current, a hyperpolarization-activated inward current, and A-type and delayed rectifier-type K(+) outward currents. Both types of K(+) outward currents were blocked by either 5 mM tetraethylammonium (TEA) or 5 mM 4-aminopyridine (4-AP). The hyperpolarization-activated current resembled the classical K(+) inward current in that it exhibited a voltage-dependent block in the presence of external Ba(2+) (30microM) or Cs(+) (3microM). However, the reversal potentials did not match well with the predicted K(+) equilibrium potentials, suggesting that it was not a classical K(+) inward rectifier current. The other Na(+) inward current resembled the classical Na(+) current observed in pharmacological studies. The expression of these channels may contribute to generation and repolarization of action potential and might be regarded as functional markers for hNSCs-derived neurons.-
dc.language.isoen-
dc.titleCharacterization of ionic currents in human neural stem cells.-
dc.typeArticle-
dc.identifier.pmid19967046-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788626/-
dc.contributor.affiliatedAuthor김, 성수-
dc.contributor.affiliatedAuthor서, 해영-
dc.contributor.affiliatedAuthor이, 영돈-
dc.type.localJournal Papers-
dc.identifier.doi10.4196/kjpp.2008.12.4.131-
dc.citation.titleKorean journal of physiology & pharmacology-
dc.citation.volume12-
dc.citation.number4-
dc.citation.date2008-
dc.citation.startPage131-
dc.citation.endPage135-
dc.identifier.bibliographicCitationKorean journal of physiology & pharmacology, 12(4). : 131-135, 2008-
dc.identifier.eissn2093-3827-
dc.relation.journalidJ012264512-
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Journal Papers > School of Medicine / Graduate School of Medicine > Anatomy
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