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Correction of target-controlled infusion following wrong selection of emulsion concentrations of propofol

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dc.contributor.authorChae, YJ-
dc.contributor.authorJoe, HB-
dc.contributor.authorLee, WI-
dc.contributor.authorKim, JA-
dc.contributor.authorMin, SK-
dc.date.accessioned2015-08-25T03:33:51Z-
dc.date.available2015-08-25T03:33:51Z-
dc.date.issued2014-
dc.identifier.issn2005-6419-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/11649-
dc.description.abstractBackground: We investigated the correction methods following wrong-settings of emulsion concentrations of propofol as a countermeasure against erroneous target-controlled infusions (TCI).



Methods: TCIs were started with targeting 4.0 μg/ml of effect-site concentration (Ceff) of propofol, and the emulsion concentrations were selected for 2.0% instead of 1.0% (FALSE1-2, n = 24), or 1.0% instead of 2.0% (FALSE2-1, n = 24). These wrong TCIs were corrected at 3 min after infusion start. During FALSE1-2, the deficit was filled up while injecting after equilibrium (n = 12), or while overriding (n = 12). During FALSE2-1, the overdose was evacuated while targeting Ceff (n = 12) or targeting plasma concentration (Cp) (n = 12). The gravimetrical measurements of TCI reproduced the Cp and Ceff using simulations. The reproduced Ceff at 3 min (Ceff-3min) and the time to be normalized within ± 5% of target Ceff (T±5%), were compared between the correction methods.



Results: During the wrong TCI, Ceff-3min was 1.98 ± 0.01 μg/ml in FALSE1-2, and 7.99 ± 0.05 μg/ml in FALSE2-1. In FALSE1-2, T±5% was significantly shorter when corrected while overriding (3.9 ± 0.25 min), than corrected after equilibrium (6.9 ± 0.05 min) (P < 0.001). In FALSE2-1, T±5% was significantly shorter during targeting Cp (3.6 ± 0.04 min) than targeting Ceff (6.7 ± 0.15 min) (P < 0.001).



Conclusions: The correction methods, based on the pharmacokinetic and pharmacodynamic characteristics, could effectively and rapidly normalize the wrong TCI following erroneously selections of the emulsion concentration of propofol.
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dc.language.isoen-
dc.titleCorrection of target-controlled infusion following wrong selection of emulsion concentrations of propofol-
dc.typeArticle-
dc.identifier.urlhttp://ekja.org/search.php?where=aview&id=10.4097/kjae.2014.66.5.377&code=0011KJAE&vmode=FULL-
dc.subject.keywordDrug delivery systems-
dc.subject.keywordInfusion pumps-
dc.subject.keywordIntravenous infusion-
dc.subject.keywordPropofol-
dc.contributor.affiliatedAuthor채, 윤정-
dc.contributor.affiliatedAuthor조, 한범-
dc.contributor.affiliatedAuthor민, 상기-
dc.type.localJournal Papers-
dc.identifier.doi10.4097/kjae.2014.66.5.377-
dc.citation.titleKorean journal of anesthesiology-
dc.citation.volume66-
dc.citation.number5-
dc.citation.date2014-
dc.citation.startPage377-
dc.citation.endPage382-
dc.identifier.bibliographicCitationKorean journal of anesthesiology, 66(5). : 377-382, 2014-
dc.identifier.eissn2005-7563-
dc.relation.journalidJ020056419-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
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