The Relationship between Serum 25Hydroxyvitamin D, Parathyroid Hormone and the Glomerular Filtration Rate in Korean Adults: The Korea National Health and Nutrition Examination Survey between 2009 and 2011

Abstract

Background: The glomerular filtration rate (GFR) decreases with age, while parathyroid hormone (PTH) increases. There

are a few reports only on the relationship between GFR and PTH under the category of serum 25-hydroxyvitamin D

(25[OH]D) concentration.

Methods: Using the Korea National Health and Nutrition Examination Survey (KNHANES) data, a cross-sectional study was

conducted on the association between serum 25(OH)D concentration, GFR and PTH in Korean adults aged 50 years or

older. Serum PTH concentration was compared to the tertiles of GFR after adjustment for relevant variables. In addition,

the serum PTH concentration was compared with the GFR under the category of serum 25(OH) D concentration (<20,

20–30, >30 ng/mL).

Results: The mean estimated GFR (eGFR) was 74.8 mL/min in men and 73.1 mL/min in women. The mean PTH and

25(OH) D was 66.8 pg/mL, 20.5 ng/mL in men and 69.0 pg/mL, 18.2 ng/mL in women. The serum PTH concentration

showed a significant negative correlation with the serum 25(OH) D and eGFR in both genders. The serum PTH

concentration significantly increased at the lower tertile of eGFR in male adults In addition, a decrease of serum PTH

concentration was marked in the vitamin D sufficient male adults (>30 ng/mL).

Conclusion: This present study demonstrated that serum PTH concentration showed negative correlation with eGFR,

however, serum PTH increase may be minimized by maintaining proper serum 25(OH)D concentrations under similar

eGFR status in Korean adults aged 50 and above.