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Regulation of proliferation by Wnt modulating protein in human mesenchymal stem cell

Lee, Na-Ra; Lee, Ji-Eun; Lee, Young-Don; Suh-Kim, Haeyoung; Kim, Sung-Soo
Department of Anatomy, Ajou University School of Medicine
Human mesenchymal stem cell (hMSC) is an attractive source of adult stem cells for the therapeutic use in regenerative medicine. These cells are usually culture expanded prior to their application. However, their proliferation and differentiation potential gradually decreases during in vitro expansion. Wingless-related MMTV integration site (Wnt) signaling is a well known signaling that implicates differentiation during development and regulates cell proliferation by gene transcription related cell growth. But the role of Wnt signaling in proliferation of hMSCs is not well known. In this study, we observed different expression levels of molecules related to Wnt-signaling. Most of Wnt signaling related protein expression were decreased with passages and so Wnt modulating protein did. The overexpression of Wnt modulating protein accelerated growth rate of hMSCs in concentration dependent manner whereas the knockdown of that decreased their proliferation rate. These observations suggested that hMSC proliferation could be regulated by Wnt signaling modulating protein.
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