Cited 0 times in Scipus Cited Count

Role of RIP3 in DNA damaging agent-induced breast cancer cell death

Other Title
DNA damaging agent에 의한 유방암 세포 사멸에서 RIP3의 역할
Authors
김, 우중
Advisor
김, 유선
Department
대학원 의생명과학과
Degree
Master (2015)
Abstract
Receptor-interacting protein kinase 3 (RIP3 or RIPK3) is a central player in “programmed” or “regulated” necrotic cell death pathway. Here we show that programmed necrosis is activated in response to chemotherapeutic agents and contributes to chemotherapy-induced breast cancer cell death. However, we also show that RIP3 expression is silenced in basal like breast cancer cell lines due to DNA methylation near its transcription start site. Due to this silencing mechanism, loss of RIP3 expression in these cells leads to resistance to DNA damaging-agents. Hypomethylating agents restore RIP3 expression and promote sensitivity not only to death receptor ligands, but also to a surprising diversity of standard chemotherapeutic agents in a RIP3-specific manner. Our data indicates that RIP3-dependent breast cancer cell death is activated in response to DNA damaging-agents. This suggests that RIP3 plays a greater role in response to DNA damaging-agents than has been previously appreciated, we propose that hypomethylating agents, in combination with standard chemotherapy, may be useful in treating breast cancers that lack RIP3 expression.
Keywords

Appears in Collections:
Theses > Graduate School of Biomedical Sciences > Master
Ajou Authors
김, 우중  |  김, 유선
Full Text Link
Files in This Item:
There are no files associated with this item.
Export

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse