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Bridging the lesioned spinal cord using hydrogel
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 김, 병곤 | - |
| dc.contributor.author | Hong, Le Thi Anh | - |
| dc.date.accessioned | 2015-10-28T02:56:30Z | - |
| dc.date.available | 2015-10-28T02:56:30Z | - |
| dc.date.issued | 2015 | - |
| dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/11835 | - |
| dc.description.tableofcontents | I. INTRODUCTION 1
A. Spinal Cord Injury 1 B. Cavity formation and the importance of bridging lesion after spinal cord injury. 2 C. Bridging cavity using biomaterials 3 D. Injectable hydrogel for contusive injury model 4 E. Aims of Study 5 II. MATERIALS AND METHODS 6 1. Animal and surgical procedures 6 2. Poly (phosphazene) hydrogel injection 6 3. Tissue processing 6 4. Immunohistochemistry 7 5. Three dimensional reconstruction of lesion cavity 7 6. Zymography 7 7. Behavioral assessment 8 III. RESULTS 10 1. Hydrogel injection prevent cavity formation after contusive spinal cord injury 10 2. Hydrogel injection suppress microglial activation 4 week after injection 14 3. Remodelling of extracellular matrix by I-5 injection 16 4. Matrixmetallo-proteinase-9 ( MMP-9) involved in ECM remodelling 20 5. Perivascular fibroblasts are a major source of the newly formed ECM at 1 and 4 week 23 6. I-5 injection promotes functional recovery 25 IV. DISCUSSION 28 V. CONCLUSION 31 | - |
| dc.format | text/plain | - |
| dc.language.iso | en | - |
| dc.title | Bridging the lesioned spinal cord using hydrogel | - |
| dc.type | Thesis | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000020728 | - |
| dc.subject.keyword | Spinal cord injury | - |
| dc.subject.keyword | hydrogel | - |
| dc.subject.keyword | extracullular matrix | - |
| dc.description.degree | Master | - |
| dc.contributor.department | 대학원 의생명과학과 | - |
| dc.contributor.affiliatedAuthor | Hong, Le Thi Anh | - |
| dc.date.awarded | 2015 | - |
| dc.type.local | Theses | - |
| dc.citation.date | 2015 | - |
| dc.embargo.liftdate | 9999-12-31 | - |
| dc.embargo.terms | 9999-12-31 | - |
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- Theses > Graduate School of Biomedical Sciences > Master
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