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Bridging the lesioned spinal cord using hydrogel

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dc.contributor.authorHong, Le Thi Anh-
dc.date.accessioned2015-10-28T02:56:30Z-
dc.date.available2015-10-28T02:56:30Z-
dc.date.issued2015-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/11835-
dc.description.tableofcontentsI. INTRODUCTION 1

A. Spinal Cord Injury 1

B. Cavity formation and the importance of bridging lesion after spinal cord injury. 2

C. Bridging cavity using biomaterials 3

D. Injectable hydrogel for contusive injury model 4

E. Aims of Study 5

II. MATERIALS AND METHODS 6

1. Animal and surgical procedures 6

2. Poly (phosphazene) hydrogel injection 6

3. Tissue processing 6

4. Immunohistochemistry 7

5. Three dimensional reconstruction of lesion cavity 7

6. Zymography 7

7. Behavioral assessment 8

III. RESULTS 10

1. Hydrogel injection prevent cavity formation after contusive spinal cord injury 10

2. Hydrogel injection suppress microglial activation 4 week after injection 14

3. Remodelling of extracellular matrix by I-5 injection 16

4. Matrixmetallo-proteinase-9 ( MMP-9) involved in ECM remodelling 20

5. Perivascular fibroblasts are a major source of the newly formed ECM at 1 and 4 week 23

6. I-5 injection promotes functional recovery 25

IV. DISCUSSION 28

V. CONCLUSION 31
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dc.formattext/plain-
dc.language.isoen-
dc.titleBridging the lesioned spinal cord using hydrogel-
dc.typeThesis-
dc.identifier.urlhttp://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000020728-
dc.subject.keywordSpinal cord injury-
dc.subject.keywordhydrogel-
dc.subject.keywordextracullular matrix-
dc.description.degreeMaster-
dc.contributor.department대학원 의생명과학과-
dc.contributor.affiliatedAuthorHong, Le Thi Anh-
dc.date.awarded2015-
dc.type.localTheses-
dc.citation.date2015-
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Theses > Graduate School of Biomedical Sciences > Master
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