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Correction of target-controlled infusion following the wrong selection of emulsion concentration of propofol

Other Title
목표농도주입법에서 프로포폴 농도를 잘못 설정 후 교정 방법
이, 원일
대학원 의학과
Master (2015)
Background: We investigated the correction methods following wrong-settings of emulsion

concentrations of propofol as a countermeasure against erroneous target-controlled infusions


Methods: TCIs were started with targeting 4.0 μg/ml of effect-site concentration (Ceff) of

propofol, and the emulsion concentrations were selected for 2.0% instead of 1.0% (FALSE1-

2, n = 24), or 1.0% instead of 2.0% (FALSE2-1, n = 24). These wrong TCIs were corrected at

3 min after infusion start. During FALSE1-2, the deficit was filled up while injecting after

equilibrium (n = 12), or while overriding (n = 12). During FALSE2-1, the overdose was

evacuated while targeting Ceff (n = 12) or targeting plasma concentration (Cp) (n = 12). The

gravimetrical measurements of TCI reproduced the Cp and Ceff using simulations. The

reproduced Ceff at 3 min (Ceff-3min) and the time to be normalized within ± 5% of target Ceff

(T±5%), were compared between the correction methods.

Results: During the wrong TCI, Ceff-3min was 1.98 ± 0.01 μg/ml in FALSE1-2, and 7.99 ± 0.05

μg/ml in FALSE2-1. In FALSE1-2, T±5% was significantly shorter when corrected while

overriding (3.9 ± 0.25 min), than corrected after equilibrium (6.9 ± 0.05 min) (P < 0.001). In

FALSE2-1, T±5% was significantly shorter during targeting Cp (3.6 ± 0.04 min) than targeting

Ceff (6.7 ± 0.15 min) (P < 0.001).

Conclusions: The correction methods, based on the pharmacokinetic and pharmacodynamic

characteristics, could effectively and rapidly normalize the wrong TCI following erroneously

selections of the emulsion concentration of propofol.
Drug delivery systemsInfusion pumpsIntravenous infusionPropofol약물 전달 시스템주입 펌프정맥 주입
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이, 원일
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