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Correction of target-controlled infusion following the wrong selection of emulsion concentration of propofol

DC Field Value Language
dc.contributor.author이, 원일-
dc.date.accessioned2015-10-28T23:56:59Z-
dc.date.available2015-10-28T23:56:59Z-
dc.date.issued2015-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/11841-
dc.description.abstractBackground: We investigated the correction methods following wrong-settings of emulsion

concentrations of propofol as a countermeasure against erroneous target-controlled infusions

(TCI).

Methods: TCIs were started with targeting 4.0 μg/ml of effect-site concentration (Ceff) of

propofol, and the emulsion concentrations were selected for 2.0% instead of 1.0% (FALSE1-

2, n = 24), or 1.0% instead of 2.0% (FALSE2-1, n = 24). These wrong TCIs were corrected at

3 min after infusion start. During FALSE1-2, the deficit was filled up while injecting after

equilibrium (n = 12), or while overriding (n = 12). During FALSE2-1, the overdose was

evacuated while targeting Ceff (n = 12) or targeting plasma concentration (Cp) (n = 12). The

gravimetrical measurements of TCI reproduced the Cp and Ceff using simulations. The

reproduced Ceff at 3 min (Ceff-3min) and the time to be normalized within ± 5% of target Ceff

(T±5%), were compared between the correction methods.

Results: During the wrong TCI, Ceff-3min was 1.98 ± 0.01 μg/ml in FALSE1-2, and 7.99 ± 0.05

μg/ml in FALSE2-1. In FALSE1-2, T±5% was significantly shorter when corrected while

overriding (3.9 ± 0.25 min), than corrected after equilibrium (6.9 ± 0.05 min) (P < 0.001). In

FALSE2-1, T±5% was significantly shorter during targeting Cp (3.6 ± 0.04 min) than targeting

Ceff (6.7 ± 0.15 min) (P < 0.001).

Conclusions: The correction methods, based on the pharmacokinetic and pharmacodynamic

characteristics, could effectively and rapidly normalize the wrong TCI following erroneously

selections of the emulsion concentration of propofol.
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dc.description.tableofcontentsⅠ.INTRODUCTION 1

Ⅱ.MATERIALS AND METHODS 2

Ⅲ.RESULTS 7

Ⅳ.DISCUSSION 11

Ⅴ.CONCLUSION 15
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dc.language.isoen-
dc.titleCorrection of target-controlled infusion following the wrong selection of emulsion concentration of propofol-
dc.title.alternative목표농도주입법에서 프로포폴 농도를 잘못 설정 후 교정 방법-
dc.typeThesis-
dc.identifier.urlhttp://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000019017-
dc.subject.keywordDrug delivery systems-
dc.subject.keywordInfusion pumps-
dc.subject.keywordIntravenous infusion-
dc.subject.keywordPropofol-
dc.subject.keyword약물 전달 시스템-
dc.subject.keyword주입 펌프-
dc.subject.keyword정맥 주입-
dc.description.degreeMaster-
dc.contributor.department대학원 의학과-
dc.contributor.affiliatedAuthor이, 원일-
dc.date.awarded2015-
dc.type.localTheses-
dc.citation.date2015-
Appears in Collections:
Theses > School of Medicine / Graduate School of Medicine > Master
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