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Human mesenchymal stem cell transplantation promotes functional recovery following acute spinal cord injury in rats.

Authors
Lee, KH; Suh-Kim, H; Choi, JS; Jeun, SS; Kim, EJ; Kim, SS; Yoon, DH; Lee, BH
Citation
Acta neurobiologiae experimentalis, 67(1):13-22, 2007
Journal Title
Acta neurobiologiae experimentalis
ISSN
0065-14001689-0035
Abstract
Many attempts have been made in animals to produce cellular regeneration in the spinal cord using a variety of transplanted cell types. The present study was to investigate whether transplantation of human mesenchymal stem cells (hMSCs) into the spinal cord after contusion injury promotes a functional outcome. Spinal cord injury (SCI) was induced using an NYU impactor and hMSCs were transplanted 1 week after SCI. Behavioral testing was performed weekly for 2 months. Somatosensory (SSEPs) and motor evoked potentials (MEPs) were recorded to determine functional recovery. Hindlimb performance was modestly improved in the transplanted group based on BBB scaling and pain tests. SSEP latencies in the transplanted group were significantly shorter than in the media-treated group. Pathologically, LacZ and hTau positive cells were located at the injury and adjacent sites. The data indicate improvement in functional outcome in animals treated with hMSC transplantation compared to media-treated animals.
MeSH terms
AdolescentAnalysis of VarianceAnimalsBehavior, AnimalChildElectric StimulationEvoked Potentials/drug effectsEvoked Potentials/physiologyFunctional Laterality/physiologyHindlimb/innervationHumansMaleMesenchymal Stem Cell Transplantation/methods*Mesenchymal Stem Cells/physiology*Nerve Tissue Proteins/metabolismNeural Conduction/physiologyRatsRats, Sprague-DawleyReaction Time/physiologyRecovery of Function/physiology*Sciatic Nerve/physiopathologySpinal Cord Injuries/pathologySpinal Cord Injuries/surgery*Transplantation, Heterologous/methods
PMID
17474317
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Journal Papers > School of Medicine / Graduate School of Medicine > Anatomy
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