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Protective effect of fucoidan against AAPH-induced oxidative stress in zebrafish model.

Authors
Kim, EA; Lee, SH; Ko, CI; Cha, SH; Kang, MC; Kang, SM; Ko, SC; Lee, WW; Ko, JY; Lee, JH; Kang, N; Oh, JY; Ahn, G; Jee, YH; Jeon, YJ
Citation
Carbohydrate polymers, 102:185-191, 2014
Journal Title
Carbohydrate polymers
ISSN
0144-86171879-1344
Abstract
Fucoidan, extracted from Ecklonia cava, has been extensively studied because of its wide biological activities. However, antioxidative activities have not been yet examined. Therefore we evaluated in vitro and in vivo studies on antioxidative activities of E. cava fucoidan (ECF). ECF exhibited more prominent effects in peroxyl radical scavenging activity, compared to the other scavenging activities. Thus, ECF was further evaluated for its protective ability against 2,2'-azobis dihydrochloride induced oxidative stress in Vero cells and ECF strongly reduced the AAPH-induced oxidative damage through scavenging intracellular reactive oxygen species. Furthermore, we evaluated protective effect of ECF against AAPH-induced oxidative stress in zebrafish model. ECF significantly reduced ROS generation, lipid peroxidation and cell death in zebrafish model. These findings indicate that ECF has antioxidant activities in vitro Vero cells and in vivo zebrafish model, even though ECF is not a polyphenol or flavonoid compound and does not contain benzene rings or conjugated structures.
MeSH terms
Amidines/pharmacologyAnimalsCercopithecus aethiopsElectron Spin Resonance SpectroscopyHeart/drug effectsLipid PeroxidationModels, AnimalOxidative Stress/drug effectsPolysaccharides/pharmacologyReactive Oxygen Species/metabolismVero CellsZebrafish
DOI
10.1016/j.carbpol.2013.11.022
PMID
24507271
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
AJOU Authors
차, 선희
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