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CSF-1R expression in tumor-associated macrophages is associated with worse prognosis in classical Hodgkin lymphoma.

DC Field Value Language
dc.contributor.authorKoh, YW-
dc.contributor.authorPark, C-
dc.contributor.authorYoon, DH-
dc.contributor.authorSuh, C-
dc.contributor.authorHuh, J-
dc.date.accessioned2015-11-23T23:17:14Z-
dc.date.available2015-11-23T23:17:14Z-
dc.date.issued2014-
dc.identifier.issn0002-9173-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/12019-
dc.description.abstractOBJECTIVES:



The aim of this study was to determine the prognostic relevance of colony-stimulating 1 receptor (CSF-1R) expression in both Hodgkin/Reed-Sternberg (HRS) cells and the surrounding cells (non-HRS cells) in patients with classical Hodgkin lymphoma (CHL) .



METHODS:



Diagnostic tissues from 112 patients with CHL treated with doxorubicin, bleomycin, vinblastine, and dacarbazine were evaluated retrospectively by immunohistochemical analysis for CSF-1R and CD68 and CD163 for tissue-associated macrophages.



RESULTS:



High numbers (≥30%) of non-HRS cells expressing CSF-1R conferred inferior event-free survival and overall survival in univariate and multivariate analysis. High numbers of non-HRS cells expressing CSF-1R were significantly associated with a high number of tumor-associated macrophages as detected by CD163 expression (P < .001). In particular, coexpression of CSF-1R and CD163 was associated with a worse survival outcome than either CSF-1R or CD163 expression alone or no expression.



CONCLUSIONS:



Our data demonstrate that a high number of non-HRS cells expressing CSF-1R are correlated with an increased tumor macrophage content and worse survival.
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dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntigens, CD-
dc.subject.MESHAntigens, Differentiation, Myelomonocytic-
dc.subject.MESHFemale-
dc.subject.MESHHodgkin Disease-
dc.subject.MESHHumans-
dc.subject.MESHMacrophages-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHReceptor, Macrophage Colony-Stimulating Factor-
dc.subject.MESHReceptors, Cell Surface-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.titleCSF-1R expression in tumor-associated macrophages is associated with worse prognosis in classical Hodgkin lymphoma.-
dc.typeArticle-
dc.identifier.pmid24619759-
dc.identifier.urlhttp://ajcp.ascpjournals.org/content/141/4/573.long-
dc.contributor.affiliatedAuthor고, 영화-
dc.type.localJournal Papers-
dc.identifier.doi10.1309/AJCPR92TDDFARISU-
dc.citation.titleAmerican journal of clinical pathology-
dc.citation.volume141-
dc.citation.number4-
dc.citation.date2014-
dc.citation.startPage573-
dc.citation.endPage583-
dc.identifier.bibliographicCitationAmerican journal of clinical pathology, 141(4). : 573-583, 2014-
dc.identifier.eissn1943-7722-
dc.relation.journalidJ000029173-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
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