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Differential expression patterns of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) -1, -4, -5, and -14 in human placenta and gestational trophoblastic diseases.

DC Field Value Language
dc.contributor.authorLee, SY-
dc.contributor.authorLee, HS-
dc.contributor.authorGil, M-
dc.contributor.authorKim, CJ-
dc.contributor.authorLee, YH-
dc.contributor.authorKim, KR-
dc.contributor.authorPark, CS-
dc.date.accessioned2015-11-23T23:34:25Z-
dc.date.available2015-11-23T23:34:25Z-
dc.date.issued2014-
dc.identifier.issn0003-9985-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/12021-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/12021-
dc.description.abstractCONTEXT:



The ability of intermediate trophoblasts to invade maternal tissue during placentation depends on how well they can degrade the extracellular matrix. Invasion into the extracellular matrix requires many complex proteases. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) is a novel family of secreted metalloproteinases. The ADAMTS-1, -4, -5, and -14 subtypes are known to be expressed in human placenta, but little is understood about their expression patterns.



OBJECTIVE:



To examine the expression patterns of ADAMTS-1, -4, -5, and -14 in specific human placenta cell types during gestation and in gestational trophoblastic diseases.



DESIGN:



Placental tissues were obtained from 25 pregnant women and 21 cases of gestational trophoblastic diseases (10 early complete moles, 3 placental site trophoblastic tumors, 4 invasive moles, and 4 choriocarcinomas). The expression of the 4 ADAMTS was analyzed by immunohistochemistry.



RESULTS:



ADAMTS-1, -4, -5, and -14 were differentially expressed by the human placenta throughout gestation in a time-specific and cell type-specific manner, as well as in gestational trophoblastic diseases. ADAMTS-1 showed gradually strong staining intensity in gestational trophoblastic diseases according to the invasive potential but showed consistent strong intensity throughout normal placenta. ADAMTS-4 and ADAMTS-5 exhibited higher and restricted expression in first-trimester intermediate trophoblasts. They also exhibited comparably strong expression in gestational trophoblastic diseases. However, ADAMTS-14 expression remained unchanged throughout gestation.



CONCLUSIONS:



The restricted expression pattern of ADAMTS-4 and ADAMTS-5 and their increased expression in gestational trophoblastic diseases suggest that these 2 ADAMTS subtypes are associated with a biological phenotype of trophoblasts involved in human placentation and the development of gestational trophoblastic diseases.
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dc.language.isoen-
dc.subject.MESHADAM Proteins/biosynthesis-
dc.subject.MESHAdult-
dc.subject.MESHChoriocarcinoma/metabolism-
dc.subject.MESHChoriocarcinoma/pathology-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Regulation-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHGestational Trophoblastic Disease/metabolism-
dc.subject.MESHGestational Trophoblastic Disease/pathology-
dc.subject.MESHHumans-
dc.subject.MESHHydatidiform Mole, Invasive/metabolism-
dc.subject.MESHHydatidiform Mole, Invasive/pathology-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPlacenta/metabolism-
dc.subject.MESHPlacenta/pathology-
dc.subject.MESHPregnancy-
dc.subject.MESHProcollagen N-Endopeptidase/biosynthesis-
dc.subject.MESHUterine Neoplasms/metabolism-
dc.subject.MESHUterine Neoplasms/pathology-
dc.titleDifferential expression patterns of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) -1, -4, -5, and -14 in human placenta and gestational trophoblastic diseases.-
dc.typeArticle-
dc.identifier.pmid24786121-
dc.contributor.affiliatedAuthor이, 용희-
dc.type.localJournal Papers-
dc.identifier.doi10.5858/arpa.2012-0227-OA-
dc.citation.titleArchives of pathology & laboratory medicine-
dc.citation.volume138-
dc.citation.number5-
dc.citation.date2014-
dc.citation.startPage643-
dc.citation.endPage650-
dc.identifier.bibliographicCitationArchives of pathology & laboratory medicine, 138(5):643-650, 2014-
dc.identifier.eissn1543-2165-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
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