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Frequency of immunoglobulin G4-related aortitis in cases with aortic resection and their clinical characteristics compared to other aortitises.

Authors
Koo, BS; Koh, YW; Hong, S; Kim, YJ; Kim, YG; Lee, CK; Yoo, B
Citation
International journal of rheumatic diseases, 17(4):420-424, 2014
Journal Title
International journal of rheumatic diseases
ISSN
1756-18411756-185X
Abstract
AIMS:



To identify the frequency of immunoglobulin G4 (IgG4)-related aortitis in patients who undergo aorta surgery and are diagnosed by pathology as having chronic aortic inflammation and to compare IgG4-related aortitis with other non-infectious aortitises in terms of clinical characteristics.



METHODS:



The aorta specimen pathological reports of 1418 patients who underwent aortic aneurysm or dissection surgery were reviewed. In total, 41 had chronic aortic inflammation without atherosclerosis, cancer or infection. Their aorta biopsy specimens were subjected to IgG4 immunostaining. IgG4-related aortitis was diagnosed if the IgG4-positive plasma cell count exceeded 50 per high power field (HPF), the ratio of IgG4-positive to IgG-positive plasma cells exceeded 50% and dense lymphoplasmacytic infiltration, fibrosis and/or obliterative phlebitis were observed.



RESULTS:



Of the 41 non-infectious aortitis cases, 29, six and six had idiopathic aortitis, Takayasu's arteritis and Behcet's aortitis, respectively. Of the 29 idiopathic aortitis cases, three had IgG4-related aortitis. All were male and > 65 years of age. Two had thoracic aortic aneurysms and one had an abdominal aortic aneurysm. Their IgG4-positive plasma cell counts were 60/HPF or higher; lymphoplasmacytic infiltration and/or fibrosis, but not obliterative phlebitis, were observed. The IgG4-related aortitis cases were older (67 [range, 65-69] years) than the Takayasu's arteritis (47.5 [38-58] years) or Behcet's aortitis (47 [31-56] years) cases and more likely to be male than the Takayasu's arteritis cases (100% vs. 17%).



CONCLUSION:



In patients with chronic aortic inflammation, 7% had IgG4-related aortitis. This disease may be more common in older male patients than in other demographic groups.
MeSH terms
AdolescentAdultAgedAneurysm, Dissecting/immunologyAneurysm, Dissecting/pathologyAneurysm, Dissecting/surgeryAortic Aneurysm/immunologyAortic Aneurysm/pathologyAortic Aneurysm/surgeryAortitis/immunologyAortitis/pathologyAortitis/surgeryBehcet Syndrome/immunologyBiological Markers/analysisBiopsyChronic DiseaseFemaleHumansImmunoglobulin G/analysisImmunohistochemistryMaleMiddle AgedPlasma Cells/immunologyRetrospective StudiesRisk FactorsTakayasu Arteritis/immunologyYoung Adult
DOI
10.1111/1756-185X.12279
PMID
24447903
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
AJOU Authors
고, 영화
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