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Expression of glycolysis-related proteins in solid papillary carcinoma of the breast according to basement membrane status.

Authors
Kwon, JE; Jung, WH; Koo, JS
Citation
Yonsei medical journal, 55(3):576-583, 2014
Journal Title
Yonsei medical journal
ISSN
0513-57961976-2437
Abstract
PURPOSE:



The aim of this study was to investigate the differences of expression in glycolysis-related proteins such as Glut-1, carbonic anhydrase (CA) IX, and monocarboxylate transporter (MCT) 4 according to the myoepithelial cell (MEC) and basement membrane (BM) status in solid papillary carcinoma (SPC) of the breast.



MATERIALS AND METHODS:



Immunohistochemical evaluation of Glut-1, CAIX, and MCT4, as well as p63 and type IV collagen, were performed on 23 SPC cases.



RESULTS:



Six and nine cases of SPC showed the presence and absence of myoepithelial cells, respectively, and eight cases belonged to the borderline status (p63-positive MEC on some areas of the outer tumor surface but not in others). BM was partially or completely absent in 14 cases and present in nine cases. SPC lacking BM more frequently showed high expression of CAIX than SPC with BM (p=0.037).



CONCLUSION:



In SPC of the breast, a strong expression of CAIX seems to be associated with an increasing degree of loss of BM, which can be interpreted as BM degradation due to the induction of extracellular acidity with increasing expression of CAIX.
MeSH terms
AdultAgedBasement Membrane/metabolismBreast Neoplasms/metabolismCarcinoma, Papillary/metabolismExcitatory Amino Acid Transporter 2/metabolismFemaleGlycolysisHumansImmunohistochemistryMiddle AgedMonocarboxylic Acid Transporters/metabolismMuscle Proteins/metabolismTumor Markers, Biological/metabolism
DOI
10.3349/ymj.2014.55.3.576
PMID
24719122
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
AJOU Authors
권, 지은
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