3 173

Cited 8 times in

MET expression is associated with disease-specific survival in breast cancer patients in the neoadjuvant setting.

Authors
Koh, YW; Lee, HJ; Ahn, JH; Lee, JW; Gong, G
Citation
Pathology, research and practice, 210(8):494-500, 2014
Journal Title
Pathology, research and practice
ISSN
0344-03381618-0631
Abstract
MET and RON receptor tyrosine kinases play an important role in tumor progression. The aim of this study was to determine the predictive or prognostic impact of MET and RON in breast cancer patients treated with neoadjuvant chemotherapy (NAC). Immunohistochemical analyses were performed to retrospectively examine the predictive or prognostic impact of MET and RON expression in 129 breast cancer patients treated with NAC followed by definitive surgical resection. MET-positive tumors were detected in 89 patients (68.9%) and RON-positive tumors in 94 patients (72.9%). Survival analysis showed that MET expression was correlated with longer disease-specific survival (DSS; P=0.016), whereas RON expression was not associated with survival rates. MET expression was a significant factor for DSS in the non-pCR group in subgroup analysis (P=0.024) and a marginal significant independent prognostic factor for DSS in multivariate analysis. The MET-positive group had higher pCR than the MET-negative group but the difference was not statistically significant (P=0.266). MET expression is a prognostic factor for DSS in breast cancer patients receiving NAC and may provide additional prognostic information in patients not achieving a pCR.
MeSH terms
AdultAgedAntineoplastic Agents/therapeutic useAntineoplastic Combined Chemotherapy Protocols/therapeutic useBreast Neoplasms/drug therapyBreast Neoplasms/metabolismBreast Neoplasms/mortalityBreast Neoplasms/pathologyCarcinoma, Ductal, Breast/drug therapyCarcinoma, Ductal, Breast/metabolismCarcinoma, Ductal, Breast/mortalityCarcinoma, Ductal, Breast/pathologyFemaleHumansMiddle AgedNeoadjuvant TherapyPrognosisProto-Oncogene Proteins c-met/metabolismReceptor Protein-Tyrosine Kinases/metabolismReceptors, Estrogen/metabolismReceptors, Progesterone/metabolismRetrospective StudiesSurvival AnalysisSurvival RateYoung Adult
DOI
10.1016/j.prp.2014.04.002
PMID
24814255
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
AJOU Authors
고, 영화
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse