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Should the cut-off values of the lymphocyte to monocyte ratio for prediction of prognosis in diffuse large B-cell lymphoma be changed in elderly patients?

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dc.contributor.authorKoh, YW-
dc.contributor.authorPark, CS-
dc.contributor.authorYoon, DH-
dc.contributor.authorSuh, C-
dc.contributor.authorHuh, J-
dc.date.accessioned2015-11-24T01:38:25Z-
dc.date.available2015-11-24T01:38:25Z-
dc.date.issued2014-
dc.identifier.issn0902-4441-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/12028-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/12028-
dc.description.abstractOBJECTIVES:



A recent study suggested a prognostic role for the peripheral blood absolute lymphocyte/monocyte ratio (LMR) at diagnosis of diffuse large B-cell lymphoma (DLBCL). Here, we investigated the significance of LMR in DLBCL patients in relation to advanced age.



METHODS:



We examined the prognostic impact of LMR in 603 DLBCL treated with rituximab plus CHOP, using the receiver operating characteristic curve analysis for optimal cut-off values, and performed a subgroup analysis according to age.



RESULTS:



In elderly groups (age ≥ 70), absolute monocyte count was significantly increased, whereas LMR was significantly decreased compared to younger groups. Patients under 70 yr of age with LMR < 3.04 had significantly lower overall survival (OS) and progression-free survival (PFS) compared to those with LMR ≥ 3.04 (P < 0.001 for both). However, in elderly patients (age ≥ 70), there was no significant difference in OS between patients' LMR levels using the 3.04 cut-off value (P = 0.059). Therefore, a new LMR cut-off value of 2.36 was selected in elderly patients, having observed that elderly patients with LMR < 2.36 had significantly lower OS compared to those with LMR ≥ 2.36 (P = 0.021). In multivariate analysis, LMR remained a significant prognostic factor for OS (P = 0.004) or PFS (P < 0.001).



CONCLUSIONS:



We suggest the use of a different cut-off value of LMR in elderly patients to distinguish high-risk from low-risk groups.
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dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAge Factors-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHFemale-
dc.subject.MESHLeukocyte Count-
dc.subject.MESHLymphocytes-
dc.subject.MESHLymphoma, Large B-Cell, Diffuse-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMonocytes-
dc.subject.MESHNeoplasm Metastasis-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHYoung Adult-
dc.titleShould the cut-off values of the lymphocyte to monocyte ratio for prediction of prognosis in diffuse large B-cell lymphoma be changed in elderly patients?-
dc.typeArticle-
dc.identifier.pmid24766257-
dc.contributor.affiliatedAuthor고, 영화-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/ejh.12354-
dc.citation.titleEuropean journal of haematology-
dc.citation.volume93-
dc.citation.number4-
dc.citation.date2014-
dc.citation.startPage340-
dc.citation.endPage348-
dc.identifier.bibliographicCitationEuropean journal of haematology, 93(4). : 340-348, 2014-
dc.identifier.eissn1600-0609-
dc.relation.journalidJ009024441-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
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