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Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns.

Authors
Yoon, S  | Park, SJ | Han, JH  | Kang, JH | Kim, JH | Lee, J | Park, S  | Shin, HJ  | Kim, K  | Yun, M | Chwae, YJ
Citation
Cell death & disease, 5. : e1494-e1494, 2014
Journal Title
Cell death & disease
ISSN
2041-4889
Abstract
Apoptosis, which is anti-inflammatory, and necrosis, which is pro-inflammatory, represent the extremes of the cell death spectrum. Cell death is complex and both apoptosis and necrosis can be observed in the same cells or tissues. Here, we introduce a novel combined mode of cellular demise--caspase-dependent regulated necrosis. Most importantly, it is mainly characterized with release of marked amount of oligo- or poly-nucleosomes and their attached damage-associated molecular patterns (DAMPs) and initiated by caspase activation. Caspase-activated DNase has dual roles in nucleosomal release as it can degrade extracellularly released chromatin into poly- or oligo-nucleosomes although it prohibits release of nucleosomes. In addition, osmotically triggered water movement following Cl(-) influx and subsequent Na(+) influx appears to be the major driving force for nucleosomal and DAMPs release. Finally, Ca(2+)-activated cysteine protease, calpain, is an another essential factor in nucleosomal and DAMPs release because of complete reversion to apoptotic morphology from necrotic one and blockade of nucleosomal and DAMPs release by its inhibition.
MeSH

DOI
10.1038/cddis.2014.450
PMID
25356863
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
Ajou Authors
김, 경민  |  박, 선  |  신, 호준  |  윤, 사라  |  최, 용준  |  한, 재호
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