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The characteristics of incidental pituitary microadenomas in 120 Korean forensic autopsy cases.

Authors
Kim, JH; Seo, JS; Lee, BW; Lee, SY; Jeon, SH; Lee, KB
Citation
Journal of Korean medical science, 22 SupplS61-S65, 2007
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
To investigate the characteristics of incidental pituitary microadenomas, we examined 120 pituitary glands from Korean forensic autopsy cases, from which eight tumors were identified (incidence 6.7%). The average age of the affected subjects was 50 yr (range: 33-96 yr) with a female predominance. The maximum diameters of the tumors ranged from 0.4 to 5.4 mm (mean: 2.8 mm). Immunohistochemical analysis of pituitary hormones revealed three growth hormone-secreting adenomas, one prolactin-producing adenoma, one gonadotropin-producing adenoma, one plurihormonal adenoma, and two null cell adenomas. MIB-1 staining for Ki-67 antigen showed no positive expression. The microvessel density (MVD) of the pituitary microadenomas ranged from 2.3 to 11.6% (mean: 5.3%) and was significantly lower than that of nonneoplastic pituitary glands (11.9-20.1%, mean: 14.8%). Our study provides reference data on incidental pituitary microadenomas in the Korean population.
MeSH terms
Adenoma/blood supplyAdenoma/epidemiologyAdenoma/metabolismAdenoma/pathology*AdultAgedAged, 80 and overAutopsyFemaleHumansImmunohistochemistryKi-67 Antigen/metabolismKorea/epidemiologyMaleMicrocirculation/pathologyMiddle AgedPituitary Hormones/metabolismPituitary Neoplasms/blood supplyPituitary Neoplasms/epidemiologyPituitary Neoplasms/metabolismPituitary Neoplasms/pathology*
DOI
10.3346/jkms.2007.22.S.S61
PMID
17923757
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
AJOU Authors
김, 장희이, 기범
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