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Effect of low serum total bilirubin levels (≤0.32 mg/dl) on risk of coronary artery disease in patients with metabolic syndrome.

DC Field Value Language
dc.contributor.authorSong, YS-
dc.contributor.authorKoo, BK-
dc.contributor.authorCho, NH-
dc.contributor.authorMoon, MK-
dc.date.accessioned2015-12-06T23:29:26Z-
dc.date.available2015-12-06T23:29:26Z-
dc.date.issued2014-
dc.identifier.issn0002-9149-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/12209-
dc.description.abstractThe objective of this study was to investigate the effects of low serum bilirubin levels on the risk for future coronary artery disease (CAD) in a prospective cohort. CAD events were examined according to baseline serum bilirubin levels in a prospective large-scale, community-based Korean cohort in 2 subsequent prospective biennial surveys. A total of 8,593 subjects were included, 0.9% of whom reported newly developed CAD events during the 4 years of follow-up. Cox regression analyses showed that the lowest serum total bilirubin level category (bilirubin ≤0.32 mg/dl) was an independent risk factor for future CAD events (adjusted hazard ratio [HR] 1.890, 95% confidence interval [CI] 1.088 to 3.284; p = 0.024). Subjects with metabolic syndrome had a higher risk for future CAD events than those without metabolic syndrome (HR 3.366, 95% CI 2.079 to 5.448, p <0.001). Low bilirubin levels increased the CAD risk in subjects with metabolic syndrome further (HR 2.016, 95% CI 1.069 to 3.800; p = 0.030), with these subjects showing a >6 times higher risk for CAD than subjects with bilirubin levels >0.32 mg/dl and no metabolic syndrome (HR 6.228, 95% CI 3.118 to 12.437; p <0.001). In conclusion, the addition of low serum bilirubin levels to the traditional risk factors for CAD, such as metabolic syndrome, may yield an improvement of risk prediction.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAge Factors-
dc.subject.MESHAged-
dc.subject.MESHBilirubin-
dc.subject.MESHCohort Studies-
dc.subject.MESHCoronary Artery Disease-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLongitudinal Studies-
dc.subject.MESHMale-
dc.subject.MESHMetabolic Syndrome X-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHProspective Studies-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRisk Factors-
dc.titleEffect of low serum total bilirubin levels (≤0.32 mg/dl) on risk of coronary artery disease in patients with metabolic syndrome.-
dc.typeArticle-
dc.identifier.pmid25288499-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pubmed/25288499-
dc.contributor.affiliatedAuthor조, 남한-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.amjcard.2014.08.043-
dc.citation.titleThe American journal of cardiology-
dc.citation.volume114-
dc.citation.number11-
dc.citation.date2014-
dc.citation.startPage1695-
dc.citation.endPage1700-
dc.identifier.bibliographicCitationThe American journal of cardiology, 114(11). : 1695-1700, 2014-
dc.identifier.eissn1879-1913-
dc.relation.journalidJ000029149-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Preventive Medicine & Public Health
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