Cited 0 times in Scipus Cited Count

Effect of interferon-lambda on replication of hepatitis B virus in human hepatoma cells.

DC Field Value Language
dc.contributor.authorHong, SH-
dc.contributor.authorCho, O-
dc.contributor.authorKim, K-
dc.contributor.authorShin, HJ-
dc.contributor.authorKotenko, SV-
dc.contributor.authorPark, S-
dc.date.accessioned2011-01-19T05:11:52Z-
dc.date.available2011-01-19T05:11:52Z-
dc.date.issued2007-
dc.identifier.issn0168-1702-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/1220-
dc.description.abstractThe antiviral activity of interferon-lambda (IFN-lambda) against several viruses has been reported, but it has not been investigated whether human IFN-lambda can affect replication of the hepatitis B virus (HBV) in human hepatocyte-derived cells. We found that replication of HBV in a human hepatoma cell line was reduced by approximately 30% following treatment with a high concentration of IFN-lambda. Furthermore, we showed that replication of HBV in another human hepatoma cell line was not suppressed by IFN-lambda. However, these cell lines showed a similar level of transcription for the heterodimeric IFN-lambda receptor and the IFN-lambda-induced antiviral proteins. Our results suggest that the antiviral activity of IFN-lambda against HBV may be limited in human cells.-
dc.language.isoen-
dc.subject.MESHAntigens, Viral-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCytokines-
dc.subject.MESHGene Expression-
dc.subject.MESHGenome, Viral-
dc.subject.MESHHepatitis B virus-
dc.subject.MESHHumans-
dc.subject.MESHInterleukins-
dc.subject.MESHReceptors, Interferon-
dc.subject.MESHRecombinant Proteins-
dc.subject.MESHTranscription, Genetic-
dc.subject.MESHVirus Replication-
dc.titleEffect of interferon-lambda on replication of hepatitis B virus in human hepatoma cells.-
dc.typeArticle-
dc.identifier.pmid17451832-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0168-1702(07)00094-9-
dc.contributor.affiliatedAuthor김, 경민-
dc.contributor.affiliatedAuthor신, 호준-
dc.contributor.affiliatedAuthor박, 선-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.virusres.2007.03.006-
dc.citation.titleVirus research-
dc.citation.volume126-
dc.citation.number1-2-
dc.citation.date2007-
dc.citation.startPage245-
dc.citation.endPage249-
dc.identifier.bibliographicCitationVirus research, 126(1-2). : 245-249, 2007-
dc.identifier.eissn1872-7492-
dc.relation.journalidJ001681702-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse