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Non-linear association of serum 25-hydroxyvitamin D with urinary albumin excretion rate in normoalbuminuric subjects.

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dc.contributor.authorOh, YJ-
dc.contributor.authorPark, RW-
dc.contributor.authorYoon, D-
dc.contributor.authorKim, M-
dc.contributor.authorHan, SS-
dc.contributor.authorJang, HR-
dc.contributor.authorKim, H-
dc.contributor.authorHeo, NJ-
dc.contributor.authorPark, SK-
dc.contributor.authorLee, H-
dc.contributor.authorJoo, KW-
dc.contributor.authorLim, CS-
dc.contributor.authorKim, YS-
dc.contributor.authorKim, DK-
dc.date.accessioned2015-12-09-
dc.date.available2015-12-09-
dc.date.issued2014-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/12220-
dc.description.abstractBACKGROUND:



Vitamin D deficiencies and increases in urinary albumin excretion (UAE) are both important and potentially related health problems; however, the nature of their relationship has not been established in normoalbuminuric subjects.



METHODS:



We obtained data from 14,594 normoalbuminuric Korean adults who underwent voluntary health screenings. We used a generalized additive model to examine the threshold level for relationship between serum 25-hydroxyvitamin D [25(OH)D] and urinary-albumin creatinine ratio (UACR) levels. We conducted multivariate logistic regression for high-normal UAE (UACR, 10-29 mg/g), according to various categories of vitamin D status.



RESULTS:



The generalized additive model confirmed a non-linear relationship between serum 25(OH)D and UACR levels, and the threshold concentration of 25(OH)D was 8.0 ng/mL after multivariate adjustment. Comparing subjects who fell into the lowest category of serum 25(OH)D levels with subjects who were in the reference range (the highest category), we observed that the multivariate adjusted odds ratio (OR) for high-normal UAE was significantly increased, regardless of the criteria used to categorize vitamin D levels: OR of the 1st quartile over the 4th quartile, 1.20 (95% CI, 1.04-1.39); OR of the 1.0-4.9th percentile over the 50-100th percentile, 1.56 (95% CI, 1.25-1.93); and OR of vitamin D deficiency group over vitamin D sufficiency group, 1.28 (95% CI, 1.08-1.52).



CONCLUSIONS:



We demonstrated that there was an inverse relationship between serum 25(OH)D less than 8.0 ng/mL and UACR in normoalbuminuric subjects, suggesting that severe vitamin D deficiency could cause an increase in UAE in subjects with normoalbuminuria.
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dc.language.isoen-
dc.subject.MESHAlbuminuria-
dc.subject.MESHAlgorithms-
dc.subject.MESHBiological Markers-
dc.subject.MESHComputer Simulation-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHModels, Biological-
dc.subject.MESHNonlinear Dynamics-
dc.subject.MESHReference Values-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHStatistics as Topic-
dc.subject.MESHVitamin D-
dc.titleNon-linear association of serum 25-hydroxyvitamin D with urinary albumin excretion rate in normoalbuminuric subjects.-
dc.typeArticle-
dc.identifier.pmid24957097-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079922/-
dc.contributor.affiliatedAuthor박, 래웅-
dc.type.localJournal Papers-
dc.identifier.doi10.1186/1471-2369-15-97-
dc.citation.titleBMC nephrology-
dc.citation.volume15-
dc.citation.date2014-
dc.citation.startPage97-
dc.citation.endPage97-
dc.identifier.bibliographicCitationBMC nephrology, 15. : 97-97, 2014-
dc.identifier.eissn1471-2369-
dc.relation.journalidJ014712369-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Biomedical Informatics
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