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Melatonin attenuates dextran sodium sulfate induced colitis with sleep deprivation: possible mechanism by microarray analysis.

Chung, SH  | Park, YS | Kim, OS | Kim, JH | Baik, HW | Hong, YO | Kim, SS | Shin, JH | Jun, JH | Jo, Y | Ahn, SB | Jo, YK | Son, BK | Kim, SH
Digestive diseases and sciences, 59(6). : 1134-1141, 2014
Journal Title
Digestive diseases and sciences
BACKGROUND: Inflammatory bowel disease is a chronic inflammatory condition of the

gastrointestinal tract. It can be aggravated by stress, like sleep deprivation,

and improved by anti-inflammatory agents, like melatonin. We aimed to investigate

the effects of sleep deprivation and melatonin on inflammation. We also

investigated genes regulated by sleep deprivation and melatonin. METHODS: In the

2% DSS induced colitis mice model, sleep deprivation was induced using modified

multiple platform water bath. Melatonin was injected after induction of colitis

and colitis with sleep deprivation. Also mRNA was isolated from the colon of mice

and analyzed via microarray and real-time PCR. RESULTS: Sleep deprivation induced

reduction of body weight, and it was difficult for half of the mice to survive.

Sleep deprivation aggravated, and melatonin attenuated the severity of colitis.

In microarrays and real-time PCR of mice colon tissues, mRNA of adiponectin and

aquaporin 8 were downregulated by sleep deprivation and upregulated by melatonin.

However, mRNA of E2F transcription factor (E2F2) and histocompatibility class II

antigen A, beta 1 (H2-Ab1) were upregulated by sleep deprivation and

downregulated by melatonin. CONCLUSION: Melatonin improves and sleep deprivation

aggravates inflammation of colitis in mice. Adiponectin, aquaporin 8, E2F2 and

H2-Ab1 may be involved in the inflammatory change aggravated by sleep deprivation

and attenuated by melatonin.

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Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Ajou Authors
정, 숙희
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