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Similar clinical characteristics of familial and sporadic inflammatory bowel disease in South Korea.

Chung, SH  | Park, SJ | Lee, HS | Hong, SP | Cheon, JH | Kim, TI | Kim, WH
World journal of gastroenterology, 20(45). : 17120-17126, 2014
Journal Title
World journal of gastroenterology
AIM: To investigate differences of clinical characteristics and disease courses

between familial and sporadic inflammatory bowel disease (IBD) patients. METHODS:

We obtained clinical data on Crohn's disease (CD) (n = 691) and ulcerative

colitis (n = 1113) from a tertiary referral medical center between 2005 and 2012.

Seventeen patients (2.5%) with CD and 27 patients (2.4%) with ulcerative colitis

(UC) were identified as having a familial history of IBD, including the first and

second degree relatives. For each control case, three times the number of age-,

sex-, and diagnosis year-matched CD and UC patients, without a family history of

IBD, were randomly selected in this case control study. RESULTS: There were no

significant differences in age or main symptom at diagnosis, extraintestinal

manifestation, location/extent, behavior of disease activity, number of

hospitalizations, number of operations, operation type, number of relapses, or

oral medical treatment between familial and sporadic CD and UC patients. Median

(min-max) follow-up periods after diagnosis of familial CD and sporadic CD

patients were 84 (24-312) and 36 (8-240) mo, respectively (P = 0.008). Familial

CD patients more frequently used anti-tumor necrosis factor (TNF) antibodies

compared to sporadic CD patients (17.6% vs 0%, P = 0.014). CONCLUSION: In

conclusion, a family history of IBD does not seem to be an important predictive

factor affecting clinical characteristics or disease course even if there is a

more frequent use of anti-TNF antibodies in familial CD patients compared to

sporadic CD patients.

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Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Ajou Authors
정, 숙희
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