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Impact of female gender on bleeding complications after transradial coronary intervention (from the Korean Transradial Coronary Intervention registry).

Authors
Shin, JS | Tahk, SJ  | Yang, HM  | Yoon, MH  | Choi, SY  | Choi, BJ  | Lim, HS  | Lee, YH | Seo, KW  | Park, SJ | Choi, YW | Yoon, J | Youn, YJ | Cho, BR | Cha, KS | Han, KR | Hyon, MS | Rha, SW | Kim, BO | Shin, WY | Park, KS | Cheong, SS | Jeong, MH
Citation
The American journal of cardiology, 113(12). : 2002-2006, 2014
Journal Title
The American journal of cardiology
ISSN
0002-91491879-1913
Abstract
Besides poor clinical outcomes, female gender has been known as a high-risk

factor for bleeding complications. This study aimed to investigate the impact of

gender on clinical outcomes and bleeding complications after transradial coronary

intervention (TRI). The Korean TRI registry is a retrospective multicenter

registry with 4,890 patients who underwent percutaneous coronary intervention in

2009 at 12 centers. To compare clinical outcomes and bleeding complications

between the male and female groups, we performed a propensity score matching in

patients who received TRI. A total of 1,194 patients (597 in each group) were

studied. The primary outcome was 1-year major adverse cardiac events, including

all-cause mortality, myocardial infarction, target vessel revascularization, and

stroke. The secondary outcome was major bleeding (composite of bleeding requiring

transfusion of >/=2 units of packed cells or bleeding that was fatal). The

proportion of major adverse cardiac events was similar between the 2 groups (6.2%

vs 4.7%, p = 0.308). The female group had a greater incidence of major bleeding

(0.3% vs 3.2%, p <0.001). On multivariate analysis, female gender (odds ratio

[OR] 7.748, 95% confidence interval [CI] 1.767 to 13.399), age >/=75 years (OR

5.824, 95% CI 2.085 to 16.274), and chronic kidney disease (OR 7.264, 95% CI

2.369 to 12.276) were independent predictors of major bleeding. In conclusion,

the female gender had a tendency for more bleeding complications than male gender

after TRI without difference in the clinical outcome.
MeSH

DOI
10.1016/j.amjcard.2014.03.042
PMID
24793670
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
Ajou Authors
서, 경우  |  양, 형모  |  윤, 명호  |  임, 홍석  |  최, 병주  |  최, 소연  |  탁, 승제
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