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Emerging invasive liver abscess caused by K1 serotype Klebsiella pneumoniae in Korea.

Authors
Chung, DR; Lee, SS; Lee, HR; Kim, HB; Choi, HJ; Eom, JS; Kim, JS; Choi, YH; Lee, JS; Chung, MH; Kim, YS; Lee, H; Lee, MS; Park, CK
Citation
The Journal of infection, 54(6):578-583, 2007
Journal Title
The Journal of infection
ISSN
0163-44531532-2742
Abstract
OBJECTIVES: The high incidence of invasive liver abscess caused by Klebsiella pneumoniae in Taiwan, contrasted with the rareness of this disease in Western countries, has aroused special interest. There have been few detailed reports from other Asian countries. To investigate a current epidemiology of K. pneumoniae liver abscess in Korea and to determine K serotype distribution in K. pneumoniae strains causing liver abscess, we performed a nationwide prospective study.



METHODS: Community-acquired, culture-proven liver abscess cases were enrolled between 2004 and 2005. Etiologies and clinical features were analyzed. K. pneumoniae isolates were serotyped according to K antigen. Meta-analysis was done to determine the time trend of the etiologies of liver abscess in Korea.



RESULTS: Out of 371 cases collected prospectively, 290 (78.2%) were caused by K. pneumoniae. Most K. pneumoniae liver abscesses were monomicrobial. Diabetes mellitus was the most common underlying disease (39.9%). Distant metastatic infections were frequently observed (8.7%). magA PCR revealed that 95 (59.4%) out of 160 K. pneumoniae isolates belonged to the K1 serotype.



CONCLUSIONS: Our study indicates that K. pneumoniae has emerged as a major etiologic agent of liver abscess in Korea, and these emerging infections seem to be attributable to invasive K. pneumoniae strains with capsular K1 serotype.
MeSH terms
AgedAntigens, Bacterial/immunologyBase SequenceCommunicable Diseases, Emerging*DNA PrimersFemaleHumansKlebsiella Infections/epidemiology*Klebsiella Infections/microbiologyKlebsiella pneumoniae/immunologyKlebsiella pneumoniae/isolation & purification*Korea/epidemiologyLiver Abscess/epidemiology*Liver Abscess/microbiologyMaleMiddle AgedProspective Studies
DOI
10.1016/j.jinf.2006.11.008
PMID
17175028
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Infectious Diseases
AJOU Authors
최, 영화
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