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The impact of age on fractional flow reserve-guided percutaneous coronary intervention: a FAME (Fractional Flow Reserve versus Angiography for Multivessel Evaluation) trial substudy.

DC Field Value Language
dc.contributor.authorLim, HS-
dc.contributor.authorTonino, PA-
dc.contributor.authorDe Bruyne, B-
dc.contributor.authorYong, AS-
dc.contributor.authorLee, BK-
dc.contributor.authorPijls, NH-
dc.contributor.authorFearon, WF-
dc.date.accessioned2016-04-14T04:13:16Z-
dc.date.available2016-04-14T04:13:16Z-
dc.date.issued2014-
dc.identifier.issn0167-5273-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/12372-
dc.description.abstractS0167-5273(14)01712-4 [pii]

AB - BACKGROUND: Fractional flow reserve (FFR)-guided percutaneous coronary

intervention (PCI) improved outcomes compared with an angiography-guided strategy

in patients with multivessel coronary artery disease (CAD). However, the effect

of age on FFR has not been well-studied. We aimed to evaluate the impact of age

on the favorable results of routine FFR-guided PCI for multivessel CAD. METHODS:

We compared 1 year outcomes between FFR-guided PCI and angiography-guided PCI in

the 512 patients enrolled in the FAME study <65 years old compared to the 493

patients >/= 65 years old. We also evaluated the effect of age on the FFR result

of varying degrees of visually estimated coronary stenosis. RESULTS: The 1-year

rate of death, myocardial infarction or repeat revascularization in the

angiography-guided group tended to be higher than in the FFR-guided group for

both those patients <65 (17.2% vs. 12.0%, P = 0.098) and those >/= 65 years old

(19.7% vs. 14.3%, P = 0.111) with no significant interaction based on age (P =

0.920). Older patients had higher FFR in vessels with 50% to 70% stenosis (0.83

+/- 0.11 vs. 0.80 +/- 0.13, P = 0.028) and in vessels with 71% to 90% stenosis

(0.69 +/- 0.15 vs. 0.65 +/- 0.16, P = 0.002). The proportion of functionally

significant lesions (FFR
significantly lower in elderly compared to younger patients (75.3% vs. 84.1%, P =

0.013). CONCLUSIONS: FFR-guided PCI is beneficial regardless of age, however,

older patients have fewer functionally significant lesions, despite a similar

angiographic appearance.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCoronary Angiography-
dc.subject.MESHCoronary Stenosis-
dc.subject.MESHCoronary Vessels-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHFractional Flow Reserve, Myocardial-
dc.subject.MESHGlobal Health-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPercutaneous Coronary Intervention-
dc.subject.MESHProspective Studies-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.titleThe impact of age on fractional flow reserve-guided percutaneous coronary intervention: a FAME (Fractional Flow Reserve versus Angiography for Multivessel Evaluation) trial substudy.-
dc.typeArticle-
dc.identifier.pmid25499342-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0167527314017124-
dc.contributor.affiliatedAuthor임, 홍석-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.ijcard.2014.09.010-
dc.citation.titleInternational journal of cardiology-
dc.citation.volume177-
dc.citation.number1-
dc.citation.date2014-
dc.citation.startPage66-
dc.citation.endPage70-
dc.identifier.bibliographicCitationInternational journal of cardiology, 177(1). : 66-70, 2014-
dc.identifier.eissn1874-1754-
dc.relation.journalidJ001675273-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
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