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Clinical course of patients with aspirin-exacerbated respiratory disease: can we predict the prognosis?

Authors
Kim, JH | Choi, GS | Kim, JE | Jin, HJ | Ye, YM  | Kim, SH  | Park, HS
Citation
Pharmacogenomics, 15(4). : 449-457, 2014
Journal Title
Pharmacogenomics
ISSN
1462-24161744-8042
Abstract
AIM: This study aimed to identify prognostic factors of aspirin-exacerbated

respiratory disease by comparing clinical and genetic data with the clinical

course. PATIENTS & METHODS: Patients were classified into two groups according to

their response to inhalation rechallenge with lysine-aspirin after at least 1

year of regular treatment with antiasthmatic medications. RESULTS: Forty eight

patients (39.3%, group I) had negative responses, whereas 74 patients (60.7%,

group II) had positive responses (n = 23) or were not rechallenged owing to

persistent symptoms (n = 51). FEV(1) at diagnosis and follow-up were

significantly lower in group II than in group I. The CCR3 polymorphism at -520T/G

differed significantly between the two groups, whereas no difference was found in

other SNPs. CONCLUSION: Baseline FEV(1) and lower lung function after treatment

were clinical factors indicating a poor prognosis of aspirin-exacerbated

respiratory disease. The G allele of CCR3 -520T>G was associated with persistent

bronchial hypersensitivity to aspirin.
MeSH

DOI
10.2217/pgs.14.2
PMID
24624912
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Hospital > Clinical Trial Center
Ajou Authors
김, 승현  |  박, 해심  |  예, 영민
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