A case of IgG4-related disease with bronchial asthma and chronic rhinosinusitis in Korea.

Abstract

IgG4-related disease (IgG4-RD) is characterized by a systemic involvement of

tumor-like lesions with IgG4-positive plasmacytes. We experienced a case of

IgG4-RD developed in a patient with bronchial asthma (BA) and chronic

rhinosinusitis (CRS). A 55-yr-old female patient with BA and CRS complained of

both eyes and neck swelling as well as a recurrent upper respiratory infection in

recent 1 yr. The serum levels of IgG4, creatinine, and pancreatic enzymes were

elevated. A biopsy of the submandibular gland showed an abundant infiltration of

IgG4-positive plasmacytes. Her symptoms remarkably improved after the treatment

of a systemic steroid that has been maintained without recurrence. We report a

rare case of IgG4-RD developed in a patient with BA and CRS.