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Increased epidermal filaggrin in chronic idiopathic urticaria is associated with severity of urticaria

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dc.contributor.authorYe, YM-
dc.contributor.authorKim, BE-
dc.contributor.authorShin, YS-
dc.contributor.authorPark, HS-
dc.contributor.authorLeung, DY-
dc.date.accessioned2016-09-30T06:51:49Z-
dc.date.available2016-09-30T06:51:49Z-
dc.date.issued2014-
dc.identifier.issn1081-1206-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/12583-
dc.description.abstractBACKGROUND: Chronic idiopathic urticaria (CIU) and atopic dermatitis (AD) are

common allergic skin diseases associated with severe pruritus. AD skin is

characterized by filaggrin deficiency, but it has not been studied in CIU.

OBJECTIVE: To compare the expression of filaggrin in skin from patients with CIU,

patients with AD, and normal controls and to investigate whether altered

filaggrin expression is associated with CIU severity. METHODS: Skin biopsies were

obtained from 16 patients with CIU, 11 patients with AD, and 14 normal controls.

Filaggrin expression was evaluated using real-time reverse transcriptase

polymerase chain reaction and immunostaining. Urticaria activity score,

transepidermal water loss, and skin pH were measured. RESULTS: FLG gene

expression was significantly greater in lesional CIU skin compared with lesional

AD skin (P < .01). The staining intensity of filaggrin was significantly

increased in lesional CIU skin compared with skin from normal controls (P < .01)

and lesional AD skin (P < .001). A significant correlation was observed between

filaggrin staining intensity and urticaria activity score in patients with CIU (r

= 0.538, P < .05). Transepidermal water loss was significantly increased in

lesional skin of patients with AD compared with skin from normal controls (P <

.01) and lesional skin from patients with CIU (P < .01). Skin pH was

significantly decreased in lesional skin from patients with CIU compared with

skin from normal controls (P < .01) and patients with AD (P < .001). CONCLUSION:

Filaggrin is overexpressed in lesional CIU skin, and increased filaggrin

expression is positively correlated with urticaria severity in CIU. Altered

filaggrin expression has physiologic effects on transepidermal water loss and pH

in the skin of patients with CIU, suggesting increased barrier function compared

with skin from patients with AD.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHDermatitis, Atopic-
dc.subject.MESHEpidermis-
dc.subject.MESHGene Expression-
dc.subject.MESHHumans-
dc.subject.MESHIntermediate Filament Proteins-
dc.subject.MESHMiddle Aged-
dc.subject.MESHUrticaria-
dc.subject.MESHWater Loss, Insensible-
dc.subject.MESHYoung Adult-
dc.titleIncreased epidermal filaggrin in chronic idiopathic urticaria is associated with severity of urticaria-
dc.typeArticle-
dc.identifier.pmid24726196-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105176/-
dc.contributor.affiliatedAuthor예, 영민-
dc.contributor.affiliatedAuthor신, 유섭-
dc.contributor.affiliatedAuthor박, 해심-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.anai.2014.03.016-
dc.citation.titleAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology-
dc.citation.volume112-
dc.citation.number6-
dc.citation.date2014-
dc.citation.startPage533-
dc.citation.endPage538-
dc.identifier.bibliographicCitationAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 112(6). : 533-538, 2014-
dc.identifier.eissn1534-4436-
dc.relation.journalidJ010811206-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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