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Autoantibodies to C-reactive protein in incomplete lupus and systemic lupus erythematosus.

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dc.contributor.authorJung, JY-
dc.contributor.authorKoh, BR-
dc.contributor.authorKim, HA-
dc.contributor.authorJeon, JY-
dc.contributor.authorSuh, CH-
dc.date.accessioned2016-10-06T02:41:51Z-
dc.date.available2016-10-06T02:41:51Z-
dc.date.issued2014-
dc.identifier.issn1081-5589-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/12606-
dc.description.abstractOBJECTIVE: Anti-C-reactive protein (CRP) antibodies have been described in

patients with systemic lupus erythematosus (SLE). We investigated the potential

of the anti-CRP antibody as a marker for disease activity in SLE patients and as

a predictor of progression to SLE in patients with incomplete lupus. METHODS:

Immunoglobulin G anti-CRP antibody levels were measured using an enzyme-linked

immunosorbent assay. RESULTS: Patients with incomplete lupus exhibited clinical

and immunologic characteristics different from those in SLE patients: no

serositis and alopecia, more common oral ulcers and arthritis, lower disease

activity index, lower positivity for antinuclear and anti-double-strand DNA

antibodies, and higher complement levels. Anti-CRP antibody levels were higher in

SLE patients (35.6 [35.1] AU) than in patients with incomplete lupus (23.1 [25.8]

AU, P = 0.016) and normal controls (21.0 [14.3] AU, P < 0.001). Anti-CRP antibody

was significantly higher in SLE patients with arthritis and correlated with

disease activity markers, including antichromatin antibody. However, no

difference in anti-CRP antibody levels was observed between patients with

incomplete lupus that progressed to SLE and those whose did not. CONCLUSION:

These data suggest that anti-CRP antibodies can neither be used as biomarkers in

SLE nor predict SLE progression in patients with incomplete lupus.
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dc.language.isoen-
dc.subject.MESHAutoantibodies-
dc.subject.MESHBiomarkers-
dc.subject.MESHC-Reactive Protein-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHImmunoglobulin G-
dc.subject.MESHLupus Erythematosus, Systemic-
dc.titleAutoantibodies to C-reactive protein in incomplete lupus and systemic lupus erythematosus.-
dc.typeArticle-
dc.identifier.pmid24896736-
dc.identifier.urlhttp://jim.bmj.com/content/62/6/890.long-
dc.contributor.affiliatedAuthor정, 주양-
dc.contributor.affiliatedAuthor김, 현아-
dc.contributor.affiliatedAuthor전, 자영-
dc.contributor.affiliatedAuthor서, 창희-
dc.type.localJournal Papers-
dc.identifier.doi10.1097/JIM.0000000000000094-
dc.citation.titleJournal of investigative medicine-
dc.citation.volume62-
dc.citation.number6-
dc.citation.date2014-
dc.citation.startPage890-
dc.citation.endPage893-
dc.identifier.bibliographicCitationJournal of investigative medicine, 62(6). : 890-893, 2014-
dc.identifier.eissn1708-8267-
dc.relation.journalidJ010815589-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
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