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Unrelated donor cord blood transplantation for non-malignant disorders in children and adolescents.

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dc.contributor.authorPark, M-
dc.contributor.authorLee, YH-
dc.contributor.authorKang, HR-
dc.contributor.authorLee, JW-
dc.contributor.authorKang, HJ-
dc.contributor.authorPark, KD-
dc.contributor.authorShin, HY-
dc.contributor.authorAhn, HS-
dc.contributor.authorBaek, HJ-
dc.contributor.authorKook, H-
dc.contributor.authorHwang, TJ-
dc.contributor.authorChung, NG-
dc.contributor.authorCho, B-
dc.contributor.authorKim, HK-
dc.contributor.authorLee, SH-
dc.contributor.authorYoo, KH-
dc.contributor.authorSung, KW-
dc.contributor.authorKoo, HH-
dc.contributor.authorKoh, KN-
dc.contributor.authorIm, HJ-
dc.contributor.authorSeo, JJ-
dc.contributor.authorPark, JE-
dc.contributor.authorLim, YJ-
dc.contributor.authorLyu, CJ-
dc.contributor.authorLee, JM-
dc.contributor.authorHah, JO-
dc.date.accessioned2016-10-17T11:23:18Z-
dc.date.available2016-10-17T11:23:18Z-
dc.date.issued2014-
dc.identifier.issn1397-3142-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/12656-
dc.description.abstractThis study analyzes the data reported to the Korean Cord Blood Registry between

1994 and 2008, involving children and adolescents with non-malignant diseases.

Sixty-five patients were evaluated in this study: SAA (n = 24), iBMFS, (n = 16),

and primary immune deficiency/inherited metabolic disorder (n = 25). The CI of

neutrophil recovery was 73.3% on day 42. By day 100, the CI of acute grade II-IV

graft-versus-host disease was 32.3%. At a median follow-up of 71 months, five-yr

OS was 50.7%. The survival rate (37.5%) and CI of neutrophil engraftment (37.5%)

were lowest in patients with iBMFS. Deaths were mainly due to infection,

pulmonary complications, and hemorrhage. In a multivariate analysis, the presence

of >3.91 x 10(5) /kg of infused CD34 + cells was the only factor consistently

identified as significantly associated with neutrophil engraftment (p = 0.04) and

OS (p = 0.03). UCBT using optimal cell doses appears to be a feasible therapy for

non-malignant diseases in children and adolescents for whom there is no

appropriate HLA-matched related donor. Strategies to reduce transplant-related

toxicities would improve the outcomes of UCBT in non-malignant diseases.
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dc.language.isoen-
dc.subject.MESHAnemia, Aplastic-
dc.subject.MESHAntigens, CD34-
dc.subject.MESHBrain Diseases, Metabolic, Inborn-
dc.subject.MESHChild, Preschool-
dc.subject.MESHCord Blood Stem Cell Transplantation-
dc.subject.MESHGraft vs Host Disease-
dc.subject.MESHHLA Antigens-
dc.subject.MESHHemoglobinuria, Paroxysmal-
dc.subject.MESHImmunologic Deficiency Syndromes-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHUnrelated Donors-
dc.titleUnrelated donor cord blood transplantation for non-malignant disorders in children and adolescents.-
dc.typeArticle-
dc.identifier.pmid24372660-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/petr.12213/abstract-
dc.contributor.affiliatedAuthor박, 준은-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/petr.12213-
dc.citation.titlePediatric transplantation-
dc.citation.volume18-
dc.citation.number2-
dc.citation.date2014-
dc.citation.startPage221-
dc.citation.endPage229-
dc.identifier.bibliographicCitationPediatric transplantation, 18(2). : 221-229, 2014-
dc.identifier.eissn1399-3046-
dc.relation.journalidJ013973142-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
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