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Tract-based spatial statistics of diffusion tensor imaging after corpus callosotomy in relation to seizure recurrence.
DC Field | Value | Language |
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dc.contributor.author | Jung, DE | - |
dc.contributor.author | Shim, WH | - |
dc.contributor.author | Yoon, HM | - |
dc.contributor.author | Kim, JA | - |
dc.contributor.author | Lee, JS | - |
dc.date.accessioned | 2016-10-19T04:59:09Z | - |
dc.date.available | 2016-10-19T04:59:09Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0256-7040 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/12673 | - |
dc.description.abstract | PURPOSE: To delineate microstructural changes in transected white matter tracts
after corpus callosotomy in relation to seizure recurrence using tract-based spatial statistics of diffusion tensor imaging (DTI-TBSS). METHODS: We retrospectively included 12 total corpus callosotomy patients who had undergone serial pre- and postoperative DTI studies. The first postoperative DTI was performed within 6 months after callosotomy. The second postoperative DTI was performed in five patients with seizure recurrence (symptomatic group) and in seven patients without seizure recurrence (asymptomatic group) after 1 year following surgery. Group comparisons of fractional anisotropy (FA) with age- and sex-matched controls were performed in a whole brain voxel-wise manner using DTI-TBSS. RESULTS: The first postoperative DTI-TBSS showed a significant FA decrease in the entire corpus callosum in all patients. The second postoperative DTI-TBSS showed that a significant FA decrease remained in the entire corpus callosum in the asymptomatic group. However, in the symptomatic group, no significant decrease of FA was observed in some parts of the posterior body and splenium of the corpus callosum, although there was still a significant FA decrease in the genu of the corpus callosum. CONCLUSIONS: Using DTI-TBSS analysis, we characterized and visualized microstructural white matter changes over time in relation to seizure recurrence in callosotomy patients, suggesting that reorganization of some transected white matter tracts may be related to seizure recurrence. DTI-TBSS analysis can provide reliable and useful information about the state of white matter bundles affected by corpus callosotomy in a noninvasive manner. | - |
dc.language.iso | en | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Anisotropy | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Corpus Callosum | - |
dc.subject.MESH | Diffusion Tensor Imaging | - |
dc.subject.MESH | Epilepsy | - |
dc.subject.MESH | Postoperative Complications | - |
dc.subject.MESH | Recurrence | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Seizures | - |
dc.title | Tract-based spatial statistics of diffusion tensor imaging after corpus callosotomy in relation to seizure recurrence. | - |
dc.type | Article | - |
dc.identifier.pmid | 25106789 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00381-014-2516-2 | - |
dc.contributor.affiliatedAuthor | 정, 다은 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1007/s00381-014-2516-2 | - |
dc.citation.title | Child's nervous system | - |
dc.citation.volume | 30 | - |
dc.citation.number | 12 | - |
dc.citation.date | 2014 | - |
dc.citation.startPage | 2043 | - |
dc.citation.endPage | 2049 | - |
dc.identifier.bibliographicCitation | Child's nervous system, 30(12). : 2043-2049, 2014 | - |
dc.identifier.eissn | 1433-0350 | - |
dc.relation.journalid | J002567040 | - |
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