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Successful treatment of pediatric systemic polyarteritis nodosa with cholestatic hepatitis.

Authors
Park, HJ; Choi, YJ; Kim, JE; Ye, YM; Park, HS; Suh, CH
Citation
Clinical rheumatology, 26(1):122-124, 2007
Journal Title
Clinical rheumatology
ISSN
0770-31981434-9949
Abstract
Polyarteritis nodosa (PAN) is a rare vasculitis in children. We report a case of 5-year-old boy with systemic PAN and cholestatic hepatitis. He had fever, abdominal pain, and gastrointestinal bleeding. Angiography revealed multiple microaneurysms in the renal, hepatic, and superior mesenteric arteries. Clinical manifestations improved slowly after immunosuppressive therapy, but liver enzyme and bilirubin levels elevated gradually. Liver biopsy findings revealed marked centrizonal canalicular cholestasis, bile duct damage, and intact hepatocyte, but there was no evidence of viral hepatitis or vasculitis. Levels of liver enzymes and bilirubin improved after two cycles of cyclophosphamide therapy. We thought that the possible etiology of elevated liver enzyme and bilirubin levels might be a manifestation of PAN.
MeSH terms
Child, PreschoolCholestasis/complicationsCholestasis/drug therapy*Cyclophosphamide/therapeutic useHepatitis/complicationsHepatitis/drug therapy*HumansImmunosuppressive Agents/therapeutic useMalePolyarteritis Nodosa/complicationsPolyarteritis Nodosa/drug therapy*
DOI
10.1007/s10067-005-0121-1
PMID
16362446
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
AJOU Authors
예, 영민박, 해심서, 창희
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