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Rosmarinic acid induces apoptosis of activated T cells from rheumatoid arthritis patients via mitochondrial pathway.
DC Field | Value | Language |
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dc.contributor.author | Hur, YG | - |
dc.contributor.author | Suh, CH | - |
dc.contributor.author | Kim, S | - |
dc.contributor.author | Won, J | - |
dc.date.accessioned | 2011-01-26T01:25:05Z | - |
dc.date.available | 2011-01-26T01:25:05Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0271-9142 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/1270 | - |
dc.description.abstract | T cells play an important role in the initiation and the progression of rheumatoid arthritis (RA) and depletion of potentially pathogenic T cells was suggested as an important therapeutic protocol. We determined if rosmarinic acid (RosA), known as a secondary metabolite from herbal plants, had apoptotic activity toward T cells from RA patients and further verified target T-cell subsets. CD3(+)CD25(+) activated T-cell subsets from most of the RA patients displayed significantly higher apoptosis rates than did the PBMCs and total CD3(+) T cells. Furthermore, activated and effector CD4(+) T cells, including CD4(+)CD25(+) and CD4(+)CD45RO(+) T cells, had a tendency of being more susceptible to RosA-induced apoptosis than that of resting and naïve T-cell subsets. RosA induced the release of cytochrome c from mitochondria and the blockage of mitochondrial depolarization inhibited apoptosis. Taken together, these results suggest that RosA induces apoptosis of activated T-cell subsets from RA patients via a mitochondrial pathway. | - |
dc.format | text/plain | - |
dc.language.iso | en | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antigens, CD3 | - |
dc.subject.MESH | Apoptosis | - |
dc.subject.MESH | Arthritis, Rheumatoid | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Cinnamates | - |
dc.subject.MESH | Cytochromes c | - |
dc.subject.MESH | Depsides | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-2 Receptor alpha Subunit | - |
dc.subject.MESH | Intracellular Membranes | - |
dc.subject.MESH | Lymphocyte Activation | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Membrane Potentials | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mitochondria | - |
dc.subject.MESH | T-Lymphocyte Subsets | - |
dc.subject.MESH | T-Lymphocytes, Regulatory | - |
dc.title | Rosmarinic acid induces apoptosis of activated T cells from rheumatoid arthritis patients via mitochondrial pathway. | - |
dc.type | Article | - |
dc.identifier.pmid | 17195044 | - |
dc.contributor.affiliatedAuthor | 서, 창희 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1007/s10875-006-9057-8 | - |
dc.citation.title | Journal of clinical immunology | - |
dc.citation.volume | 27 | - |
dc.citation.number | 1 | - |
dc.citation.date | 2007 | - |
dc.citation.startPage | 36 | - |
dc.citation.endPage | 45 | - |
dc.identifier.bibliographicCitation | Journal of clinical immunology, 27(1). : 36-45, 2007 | - |
dc.identifier.eissn | 1573-2592 | - |
dc.relation.journalid | J002719142 | - |
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