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Significant association of FcepsilonRIalpha promoter polymorphisms with aspirin-intolerant chronic urticaria.

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dc.contributor.authorBae, JS-
dc.contributor.authorKim, SH-
dc.contributor.authorYe, YM-
dc.contributor.authorYoon, HJ-
dc.contributor.authorSuh, CH-
dc.contributor.authorNahm, DH-
dc.contributor.authorPark, HS-
dc.date.accessioned2011-01-26T01:29:20Z-
dc.date.available2011-01-26T01:29:20Z-
dc.date.issued2007-
dc.identifier.issn0091-6749-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/1271-
dc.description.abstractBACKGROUND: Although the mechanism that underlies aspirin hypersensitivity is not completely understood, an IgE-mediated response was reported for a patient with aspirin-intolerant chronic urticaria (AICU).



OBJECTIVE: We investigated whether genetic polymorphisms on the alpha-chain of the high-affinity IgE receptor (FcepsilonRIalpha) gene were associated with the AICU phenotype.



METHODS: We genotyped 2 promoter polymorphisms (-344C>T and -95T>C) of FcepsilonRIalpha gene in the Korean population, and the functional effect of the -344C>T polymorphism was analyzed by using a luciferase reporter assay and an electrophoretic mobility shift assay.



RESULTS: The rare allele frequency of the -344C>T polymorphism was significantly higher in the patients with AICU compared with the other subjects (P= .008 for AICU vs aspirin-tolerant chronic urticaria; P= .03 for AICU vs controls). This polymorphism was also significantly associated with total serum IgE concentrations and a higher rate of atopy in the patients with AICU (P= .01 and .05, respectively). The reporter plasmid that carried the -344T allele exhibited significantly higher promoter activity in a rat mast cell line (RBL-2H3) compared with the promoter activity of the -344C allele (P< .001). We found that transcription factor Myc-associated zinc finger protein preferentially bound the -344C promoter. Moreover, patients with AICU with the heterozygous CT genotype of the -344C>T polymorphism exhibited greater anti-IgE-mediated histamine release compared with those with the homozygous CC genotype.



CONCLUSION: These results suggest that the -344C>T polymorphism of the FcepsilonRIalpha promoter may be associated with increased expression of FcepsilonRIalpha on mast cells and enhanced release of histamine.



CLINICAL IMPLICATIONS: The FcepsilonRIalpha -344C>T polymorphism may contribute to the development of AICU.
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dc.language.isoen-
dc.subject.MESHAspirin-
dc.subject.MESHBasophils-
dc.subject.MESHChronic Disease-
dc.subject.MESHDNA-Binding Proteins-
dc.subject.MESHDrug Hypersensitivity-
dc.subject.MESHHistamine Release-
dc.subject.MESHHumans-
dc.subject.MESHPolymorphism, Single Nucleotide-
dc.subject.MESHPromoter Regions, Genetic-
dc.subject.MESHReceptors, IgE-
dc.subject.MESHTranscription Factors-
dc.subject.MESHUrticaria-
dc.titleSignificant association of FcepsilonRIalpha promoter polymorphisms with aspirin-intolerant chronic urticaria.-
dc.typeArticle-
dc.identifier.pmid17125826-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0091-6749(06)02120-8-
dc.contributor.affiliatedAuthor김, 승현-
dc.contributor.affiliatedAuthor예, 영민-
dc.contributor.affiliatedAuthor서, 창희-
dc.contributor.affiliatedAuthor남, 동호-
dc.contributor.affiliatedAuthor박, 해심-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.jaci.2006.10.006-
dc.citation.titleThe Journal of allergy and clinical immunology-
dc.citation.volume119-
dc.citation.number2-
dc.citation.date2007-
dc.citation.startPage449-
dc.citation.endPage456-
dc.identifier.bibliographicCitationThe Journal of allergy and clinical immunology, 119(2). : 449-456, 2007-
dc.identifier.eissn1097-6825-
dc.relation.journalidJ000916749-
Appears in Collections:
Journal Papers > Hospital > Clinical Trial Center
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
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