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Pretreatment selection of regimen according to genetic analysis improves the efficacy of chemotherapy in the first line treatment of metastatic colorectal cancer.

Authors
Kim, DY  | Paek, TY | Oh, SY  | Kim, YB  | Lee, JH  | Lee, MY | Choi, ZS | Suh, KW
Citation
Journal of surgical oncology, 109(3). : 250-254, 2014
Journal Title
Journal of surgical oncology
ISSN
0022-47901096-9098
Abstract
BACKGROUND AND OBJECTIVES: Metastatic colon cancer patients are treated with the

chemotherapy regimens, FOLFOX and FOLFIRI, in either order. So far, we cannot

predict the response of chemotherapeutic agent, so it is necessary to find which

regimen is adequate before starting chemotherapy. METHODS: Enrolled patients are

randomized into either conventional treatment or planned treatment preceded by

pretreatment genetic analysis. Blood samples of patients in planned treatment

group (N = 53) were analyzed for the genetic polymorphism before selection of

chemotherapeutic agents. Target genes were XPD-751, GSTP-1-105, XRCC1-399 for

oxaliplatin, UGT1A1 for irinotecan. The response was measured by computed

tomographic scan after completion of three cycles of chemotherapy. RESULTS:

Overall response rate was significantly higher in planned group (67.9% vs. 46.3%,

P = 0.020). In FOLFOX group, response rate was significantly improved in the

planned patients(77.1% vs. 50%, P = 0.018). In FOLFIRI group, the difference

didn't reach statistical significance (50% vs. 42.5%, P = 0.776). CONCLUSIONS: We

found significantly improved response rates in the chemotherapy of metastatic

colon cancer by pretreatment genetic analysis, especially in FOLFOX group.
MeSH

DOI
10.1002/jso.23500
PMID
24318863
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
Ajou Authors
김, 도윤  |  김, 영배  |  서, 광욱  |  오, 승엽  |  이, 제희
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