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Cytotoxic T lymphocyte-associated antigen-4 gene polymorphisms confer susceptibility to atopic asthma in Korean children.

Authors
Sohn, MH; Kim, SH; Song, TW; Kim, KW; Kim, ES; Park, HS; Kim, KE
Citation
Pediatric pulmonology, 42(6):542-547, 2007
Journal Title
Pediatric pulmonology
ISSN
8755-68631099-0496
Abstract
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a negative regulator of T lymphocyte activation. The gene encoding CTLA-4 is a candidate gene for conferring susceptibility to allergic disease. The purpose of this study was to evaluate the potential effects of CTLA-4 gene polymorphisms in Korean children on asthma. We genotyped 272 children with atopic asthma, 54 children with nonatopic asthma (NAA), and 254 control children for allelic determinants at two polymorphic sites in the region at positions promoter - 318 C > T and exon 1 + 49 G > A using restriction fragment length polymorphism methods. As a result, allele and genotype frequencies of the CTLA-4 exon 1 + 49 G > A polymorphism were different to some extent between the atopic asthma children and the controls with P<0.05, which did not reach statistical significance after the correction of multiple comparisons. In addition, CTLA-4 + 49 G > A polymorphism was significantly associated with elevated serum IgE levels (P=0.01). Of the four haplotype, haplotype 1 (C-G) was only associated with atopic asthma susceptibility after the correction of multiple comparisons (P=0.01, OR=0.702, 95% CI= 0.541-0.911). Polymorphisms in the CTLA-4 gene likely confer susceptibility to atopic asthma in Korean children.
MeSH terms
AdolescentAllelesAntigens, CD/genetics*Antigens, Differentiation/genetics*Asthma/ethnology*Asthma/genetics*Asthma/immunologyCase-Control StudiesChildExons/geneticsFemaleGenetic Markers/geneticsGenetic Predisposition to Disease/ethnology*GenotypeHaplotypes/geneticsHumansImmunoglobulin E/bloodKorea/ethnologyMalePolymorphism, Genetic/genetics*
DOI
10.1002/ppul.20622
PMID
17469155
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Research Organization > Regional Clinical Trial Center
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