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Histomorphochemical comparison of microfracture as a first-line and a salvage procedure: is microfracture still a viable option for knee cartilage repair in a salvage situation?

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dc.contributor.authorTruong, MD-
dc.contributor.authorChung, JY-
dc.contributor.authorKim, YJ-
dc.contributor.authorJin, LH-
dc.contributor.authorKim, BJ-
dc.contributor.authorChoi, BH-
dc.contributor.authorMin, BH-
dc.date.accessioned2016-11-02T01:21:03Z-
dc.date.available2016-11-02T01:21:03Z-
dc.date.issued2014-
dc.identifier.issn0736-0266-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/12765-
dc.description.abstractMicrofracture is considered as the first-line procedure for knee cartilage

repair, but the results of microfracture seem less predictable and rather

controversial in a salvage situation. Thus, the purpose of the study was to

histomorphochemically compare microfracture as a salvage procedure with

microfracture as a first-line procedure in a rabbit model. We hypothesized that

microfracture in a salvage situation would result in histomorphochemically

inferior cartilage repair compared to microfracture as a first-line procedure,

and the inferiority would be attributed to less migration of reparable marrow

cells to the defect due to destruction of microarchitecture of the subchondral

bone. Thirty-six New Zealand white rabbits were divided into three groups: (i)

untreated full-thickness chondral defect, (ii) single microfracture treatment

(first microfracture group), and (iii) repeated microfracture in 8 weeks after

the first procedure (second microfracture group). In each group, rabbits were

sacrificed at the end of 8 weeks, and osteochondral specimens at the repair sites

were obtained for histomorphochemical analysis. Results showed that microfracture

as a salvage procedure resulted in overall inferior cartilage repair

histomorphochemically compared with microfracture as a first-line procedure,

which correlated with deteriorative changes in the quality of underlying

subchondral bone rather than intrinsic incapability to recruit the reparative

cells in the defect area. In conclusion, although a comparable number of

reparable cells and a mechanically weakened subchondral bone are anticipated,

more study is necessary to clearly determine when a microfracture should be

performed in a situation.
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dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHArthroplasty, Subchondral-
dc.subject.MESHBone Density-
dc.subject.MESHCartilage-
dc.subject.MESHColony-Forming Units Assay-
dc.subject.MESHKnee Injuries-
dc.subject.MESHRabbits-
dc.subject.MESHReoperation-
dc.subject.MESHSalvage Therapy-
dc.subject.MESHWound Healing-
dc.titleHistomorphochemical comparison of microfracture as a first-line and a salvage procedure: is microfracture still a viable option for knee cartilage repair in a salvage situation?-
dc.typeArticle-
dc.identifier.pmid24676881-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/jor.22592/abstract-
dc.contributor.affiliatedAuthor정, 준영-
dc.contributor.affiliatedAuthor김, 영직-
dc.contributor.affiliatedAuthor민, 병현-
dc.type.localJournal Papers-
dc.identifier.doi10.1002/jor.22592-
dc.citation.titleJournal of orthopaedic research-
dc.citation.volume32-
dc.citation.number6-
dc.citation.date2014-
dc.citation.startPage802-
dc.citation.endPage810-
dc.identifier.bibliographicCitationJournal of orthopaedic research, 32(6). : 802-810, 2014-
dc.identifier.eissn1554-527X-
dc.relation.journalidJ007360266-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Orthopedic Surgery
Journal Papers > Research Organization > Cell Therapy Center
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