123 548

Cited 0 times in

Red ginseng delays age-related hearing and vestibular dysfunction in C57BL/6 mice.

DC Field Value Language
dc.contributor.authorTian, C-
dc.contributor.authorKim, YJ-
dc.contributor.authorLim, HJ-
dc.contributor.authorKim, YS-
dc.contributor.authorPark, HY-
dc.contributor.authorChoung, YH-
dc.date.accessioned2016-11-11T04:30:54Z-
dc.date.available2016-11-11T04:30:54Z-
dc.date.issued2014-
dc.identifier.issn0531-5565-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/12827-
dc.description.abstractSince Korean red ginseng (KRG) has been proven to protect against

gentamicin-induced vestibular and hearing dysfunction, the effects of KRG on

age-related inner ear disorder in C57BL/6 mice were investigated. While

age-related hearing loss was detected at the age of 6months (32kHz) and 9months

(16kHz) in the control group, it was significantly delayed (p<0.05) in the

150mg/kg KRG-treated group. Vestibular dysfunction was observed in the

tail-hanging and swimming tests, with significantly different severity scores and

swimming times detected between the control and 150mg/kg KRG-treated group at the

age of 12months (p<0.05). Mice treated with 500mg/kg KRG exhibited irritability

and aggravated inner ear dysfunction. Histological observation supported the

findings of hearing and vestibular function defects. In conclusion, C57BL/6 mice

showed early-onset hearing loss and progressive vestibular dysfunction with

aging, which were delayed by treatment with 150mg/kg KRG. However, 500mg/kg KRG

treatment may induce aggressive behavior.
-
dc.language.isoen-
dc.subject.MESHAging/drug effects-
dc.subject.MESHAnimals-
dc.subject.MESHCytochromes c/metabolism-
dc.subject.MESHDrug Evaluation, Preclinical-
dc.subject.MESHHair Cells, Auditory/drug effects/ultrastructure-
dc.subject.MESHHearing Loss/metabolism/prevention & control-
dc.subject.MESHMedicine, Korean Traditional-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHPanax-
dc.subject.MESHPhytotherapy-
dc.subject.MESHPlant Extracts/pharmacology/therapeutic use-
dc.subject.MESHRandom Allocation-
dc.subject.MESHVestibular Diseases/metabolism/prevention & control-
dc.subject.MESHbcl-X Protein/metabolism-
dc.titleRed ginseng delays age-related hearing and vestibular dysfunction in C57BL/6 mice.-
dc.typeArticle-
dc.identifier.pmid24952098-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0531556514001995-
dc.contributor.affiliatedAuthor전, 춘걸-
dc.contributor.affiliatedAuthor임, 혜진-
dc.contributor.affiliatedAuthor박, 헌이-
dc.contributor.affiliatedAuthor정, 연훈-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.exger.2014.06.013-
dc.citation.titleExperimental gerontology-
dc.citation.volume57-
dc.citation.date2014-
dc.citation.startPage224-
dc.citation.endPage232-
dc.identifier.bibliographicCitationExperimental gerontology, 57. : 224-232, 2014-
dc.identifier.eissn1873-6815-
dc.relation.journalidJ005315565-
Appears in Collections:
Journal Papers > Research Organization > Inflamm-aging Translational Research Center
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
Files in This Item:
24952098.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse