Cited 0 times in Scipus Cited Count

Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus.

Authors
Chun, HY | Chung, JW | Kim, HA  | Yun, JM | Jeon, JY | Ye, YM | Kim, SH  | Park, HS  | Suh, CH
Citation
Journal of clinical immunology, 27(5). : 461-466, 2007
Journal Title
Journal of clinical immunology
ISSN
0271-91421573-2592
Abstract
There is a great deal of interest in the identification of biomarkers that are closely associated with disease activity in systemic lupus erythematosus (SLE), but few biomarkers have been validated. Cytokines play an important role in the pathogenesis of SLE. Therefore, we evaluated the levels of cytokines and their possible association with disease activity. In the present study, we found that the SLE patients had higher IL-6, IL-10, IL-12, and IFN-gamma levels, but lower IL-2, than normal controls. Serum IL-6 level was significantly elevated in active SLE patients and correlated with the SLE activity index (SLEDAI), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Serum IL-10 level was also significantly elevated in active SLE patients and revealed positive correlation with SLEDAI and anti-double-stranded DNA (dsDNA) titer and negative correlation with C3, C4, and lymphocyte counts. No significant differences in the levels of cytokines were observed between SLE patients with nephritis and those without nephritis. These data suggest that IL-6 and IL-10 may be a useful biomarker for disease activity in SLE.
MeSH

DOI
10.1007/s10875-007-9104-0
PMID
17587156
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
Journal Papers > Hospital > Clinical Trial Center
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Ajou Authors
김, 승현  |  김, 현아  |  박, 해심  |  서, 창희
Files in This Item:
There are no files associated with this item.
Export

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse