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Differential contribution of the CysLTR1 gene in patients with aspirin hypersensitivity.

Authors
Kim, SH; Yang, EM; Park, HJ; Ye, YM; Lee, HY; Park, HS
Citation
Journal of clinical immunology, 27(6):613-619, 2007
Journal Title
Journal of clinical immunology
ISSN
0271-91421573-2592
Abstract
In this study, we compared the roles of CysLT receptor type 1 (CysLTR1) and leukotriene C4 synthase (LTC4S) gene polymorphisms in two major aspirin-related allergic diseases, aspirin-intolerant asthma (AIA) and aspirin-induced chronic urticaria/angioedema (AICU). CysLTR1-634C>T and LTC4S-444A>C polymorphisms were genotyped and its functional effect on the promoter activity was compared. As in vivo functional study, changes of peripheral mRNA level of CysLTR1 were measured by real-time PCR before and after aspirin challenge. A significant association was found for the CysLTR1 promoter polymorphism and the AIA phenotype compared to AICU (P = 0.015). In U937 cells, the variant genotype reporter construct showed significantly higher promoter activity than the common genotype (P < 0.05). The CysLTR1 mRNA levels increased significantly after aspirin challenge in AIA patients (P = 0.013). In conclusion, the CysLTR1 polymorphism may contribute to develop to the AIA phenotype and be used as a genetic marker for differentiating two major aspirin hypersensitivity phenotypes.
MeSH terms
AdultAspirin/adverse effects*Asthma/geneticsAsthma/immunologyCase-Control StudiesDiagnosis, DifferentialDrug Hypersensitivity/diagnosisDrug Hypersensitivity/enzymologyDrug Hypersensitivity/genetics*Drug Hypersensitivity/immunologyFemaleGenetic MarkersGlutathione Transferase/geneticsHumansHypersensitivity, Immediate/diagnosisHypersensitivity, Immediate/geneticsHypersensitivity, Immediate/immunologyMaleMembrane Proteins/genetics*PhenotypePolymorphism, Single NucleotidePromoter Regions, GeneticReceptors, Leukotriene/genetics*U937 CellsUrticaria/geneticsUrticaria/immunology
DOI
10.1007/s10875-007-9115-x
PMID
17641958
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Research Organization > Regional Clinical Trial Center
AJOU Authors
김, 승현박, 해심
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