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Is there any correlation between model-based perfusion parameters and model-free parameters of time-signal intensity curve on dynamic contrast enhanced MRI in breast cancer patients?

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dc.contributor.authorYi, B-
dc.contributor.authorKang, DK-
dc.contributor.authorYoon, D-
dc.contributor.authorJung, YS-
dc.contributor.authorKim, KS-
dc.contributor.authorYim, H-
dc.contributor.authorKim, TH-
dc.date.accessioned2016-11-15-
dc.date.available2016-11-15-
dc.date.issued2014-
dc.identifier.issn0938-7994-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/12866-
dc.description.abstractOBJECTIVE: To find out any correlation between dynamic contrast-enhanced (DCE)

model-based parameters and model-free parameters, and evaluate correlations

between perfusion parameters with histologic prognostic factors. METHODS:

Model-based parameters (Ktrans, Kep and Ve) of 102 invasive ductal carcinomas

were obtained using DCE-MRI and post-processing software. Correlations between

model-based and model-free parameters and between perfusion parameters and

histologic prognostic factors were analysed. RESULTS: Mean Kep was significantly

higher in cancers showing initial rapid enhancement (P = 0.002) and a delayed

washout pattern (P = 0.001). Ve was significantly lower in cancers showing a

delayed washout pattern (P = 0.015). Kep significantly correlated with time to

peak enhancement (TTP) (rho = -0.33, P < 0.001) and washout slope (rho = 0.39, P

= 0.002). Ve was significantly correlated with TTP (rho = 0.33, P = 0.002). Mean

Kep was higher in tumours with high nuclear grade (P = 0.017). Mean Ve was lower

in tumours with high histologic grade (P = 0.005) and in tumours with negative

oestrogen receptor status (P = 0.047). TTP was shorter in tumours with negative

oestrogen receptor status (P = 0.037). CONCLUSIONS: We could acquire general

information about the tumour vascular physiology, interstitial space volume and

pathologic prognostic factors by analyzing time-signal intensity curve without a

complicated acquisition process for the model-based parameters. KEY POINTS: * Kep

mainly affected the initial and delayed curve pattern in time-signal intensity

curve. * There is significant correlation between model-based and model-free

parameters. * We acquired information about tumour vascular physiology,

interstitial space volume and prognostic factors.
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dc.language.isoen-
dc.subject.MESHAged-
dc.subject.MESHBreast Neoplasms-
dc.subject.MESHCarcinoma, Ductal, Breast-
dc.subject.MESHContrast Media-
dc.subject.MESHEarly Detection of Cancer-
dc.subject.MESHHumans-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHOrganometallic Compounds-
dc.subject.MESHPerfusion Imaging-
dc.subject.MESHRetrospective Studies-
dc.titleIs there any correlation between model-based perfusion parameters and model-free parameters of time-signal intensity curve on dynamic contrast enhanced MRI in breast cancer patients?-
dc.typeArticle-
dc.identifier.pmid24553785-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00330-014-3100-6-
dc.contributor.affiliatedAuthor강, 두경-
dc.contributor.affiliatedAuthor정, 용식-
dc.contributor.affiliatedAuthor김, 구상-
dc.contributor.affiliatedAuthor임, 현이-
dc.contributor.affiliatedAuthor김, 태희-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s00330-014-3100-6-
dc.citation.titleEuropean radiology-
dc.citation.volume24-
dc.citation.number5-
dc.citation.date2014-
dc.citation.startPage1089-
dc.citation.endPage1096-
dc.identifier.bibliographicCitationEuropean radiology, 24(5). : 1089-1096, 2014-
dc.identifier.eissn1432-1084-
dc.relation.journalidJ009387994-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
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