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Association of beta2-Adrenergic Receptor Polymorphism with the Phenotype of Aspirin-Intolerant Acute Urticaria.

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dc.contributor.authorKim, HA-
dc.contributor.authorYe, YM-
dc.contributor.authorKim, SH-
dc.contributor.authorHur, GY-
dc.contributor.authorPark, HS-
dc.date.accessioned2011-01-26T02:59:53Z-
dc.date.available2011-01-26T02:59:53Z-
dc.date.issued2007-
dc.identifier.issn0513-5796-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/1287-
dc.description.abstractThe genetic mechanism of aspirin intolerant acute urticaria (AIAU) is unknown. To demonstrate an association between the beta2 adrenergic receptor (ADRB2) polymorphism and the phenotype of AIAU, one hundred fourteen patients with AIAU, 110 patients with aspirin intolerant chronic urticaria (AICU), and 498 normal healthy controls (NC) based on a Korean population were enrolled. The genotype of ADRB2 at 46 A > G was analyzed using a direct sequencing method. The ADRB2 polymorphism at 46 A > G showed a significant difference between AIAU and NC; the frequency of the major genotype was significantly higher in the AIAU group (p= 0.017 in recessive model), while no differences were noted in allele and genotype frequencies between AICU and NC. In conclusion, the ADRB2 (46 A > G) gene polymorphism may contribute to the development of the phenotype of AIAU.-
dc.language.isoen-
dc.titleAssociation of beta2-Adrenergic Receptor Polymorphism with the Phenotype of Aspirin-Intolerant Acute Urticaria.-
dc.typeArticle-
dc.contributor.affiliatedAuthor김, 현아-
dc.contributor.affiliatedAuthor김, 승현-
dc.contributor.affiliatedAuthor허, 규영-
dc.contributor.affiliatedAuthor박, 해심-
dc.type.localJournal Papers-
dc.citation.titleYonsei medical journal-
dc.citation.volume48-
dc.citation.number6-
dc.citation.date2007-
dc.citation.startPage1079-
dc.citation.endPage1081-
dc.identifier.bibliographicCitationYonsei medical journal, 48(6). : 1079-1081, 2007-
dc.identifier.eissn1976-2437-
dc.relation.journalidJ005135796-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
Journal Papers > Hospital > Clinical Trial Center
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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