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Repeated-Binge Ethanol Intoxication Leads to Lower Choline-Containing Compound Signals in Adult Rats: An In Vivo Marker of Ethanol-Induced Neurochemical Abnormalities

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dc.contributor.authorLee, DW-
dc.contributor.authorPark, JY-
dc.contributor.authorKim, SY-
dc.contributor.authorPark, HJ-
dc.contributor.authorLee, SR-
dc.contributor.authorSuh, TS-
dc.contributor.authorChoe, BY-
dc.date.accessioned2016-11-17T06:23:28Z-
dc.date.available2016-11-17T06:23:28Z-
dc.date.issued2014-
dc.identifier.issn0937-9347-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/12886-
dc.description.abstractEthanol is the most commonly abused intoxicating substance among young and middle-aged adults, and ranks highly as a cause of disability and mortality. A pattern of heavy consumption, called binge drinking, leads to various psychiatric disorders. However, to the best of our knowledge, assessments of the influence of short-term binge ethanol (SBE) intoxication on cerebral metabolite changes in human and rat models are scarce. We used in vivo 1H magnetic resonance spectroscopy (1H-MRS) to quantitatively assess neurochemical responses in hippocampus in a rat model of SBE intoxication. Seven SBE-exposed rats received an initial dose of 5.0-g/kg ethanol (30 %-w/v solution) through gavage and additional doses of 2.0-g/kg ethanol (25 %-w/v solution), every 8 hour for 4 days. Six rats in sham control group (CNTL) received an equivalent volume of distilled water at comparable times. Sixty minutes after last gavage session, in vivo 1H-MRS scans were obtained from all rats using a 4.7 Tesla animal scanner. For neurochemical analysis, a single voxel was positioned in the hippocampal region and spectra were fitted for the quantification of 17 cerebral neurochemical signals. In hippocampus, the concentration of total choline-containing compound signals (tCho: [glycerophosphocholine] + [phosphocholine]) was significantly lower in SBE-exposed rats than in CNTL rats. Moreover, gamma-aminobutyric acid (GABA)/total creatine (tCr: creatine + phosphocreatine), tCho/tCr, and tCho/total N-acetyl-aspartate (tNAA: N-acetyl-aspartate + N-acetyl-aspartyl-glutamate) ratios were significantly lower in SBE-exposed rats than CNTL rats. We determined that tCho, GABA, and tNAA signals were highly sensitive to short-term binge ethanol intoxication, which provides insights into neurochemical alterations associated with ethanol abuse.-
dc.language.isoen-
dc.titleRepeated-Binge Ethanol Intoxication Leads to Lower Choline-Containing Compound Signals in Adult Rats: An In Vivo Marker of Ethanol-Induced Neurochemical Abnormalities-
dc.typeArticle-
dc.identifier.urlhttp://link.springer.com/article/10.1007/s00723-014-0585-8-
dc.contributor.affiliatedAuthor박, 혜진-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s00723-014-0585-8-
dc.citation.titleApplied magnetic resonance-
dc.citation.volume45-
dc.citation.number12-
dc.citation.date2014-
dc.citation.startPage1377-
dc.citation.endPage1388-
dc.identifier.bibliographicCitationApplied magnetic resonance, 45(12). : 1377-1388, 2014-
dc.relation.journalidJ009379347-
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Journal Papers > School of Medicine / Graduate School of Medicine > Radiation Oncology
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