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Prognostic significance of the intratumoral heterogeneity of (18) F-FDG uptake in oral cavity cancer.

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dc.contributor.authorKwon, SH-
dc.contributor.authorYoon, JK-
dc.contributor.authorAn, YS-
dc.contributor.authorShin, YS-
dc.contributor.authorKim, CH-
dc.contributor.authorLee, DH-
dc.contributor.authorJo, KS-
dc.contributor.authorLee, SJ-
dc.date.accessioned2016-11-17T06:47:22Z-
dc.date.available2016-11-17T06:47:22Z-
dc.date.issued2014-
dc.identifier.issn0022-4790-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/12892-
dc.description.abstractBACKGROUNDS: We evaluated the prognostic value of the intratumoral heterogeneity

of (18) F-FDG uptake in oral cavity cancer. MATERIALS AND METHODS: We enrolled 45

patients who underwent pretreatment (18) F-FDG PET/CT. The intratumoral

heterogeneity of (18) F-FDG uptake was represented as the heterogeneity factor

(HF), defined as the derivative (dV/dT) of a volume-threshold function for a

primary tumor. We measured the maximum standardized uptake value (SUVmax ) and

volumetric PET parameters. The relationship between HF and clinical parameters,

as well as other PET parameters, was evaluated. RESULTS: The HF was significantly

correlated with SUVmax (r = -0.353, P = 0.017), metabolic tumor volume (r =

-0.708, P < 0.0001), and total lesion glycolysis (r = -0.709, P < 0.0001). A

multivariate analysis revealed not only cervical lymph node metastasis (hazard

ratio = 5.983; P = 0.022) but also HF (hazard ratio = 2.49 x 10(-4) ; P = 0.002)

to be independent predictors of overall survival. Those patients with HF < -0.13

showed a worse prognosis than those with HF >/= -0.13 (P = 0.005). CONCLUSIONS:

The intratumoral heterogeneity of (18) F-FDG uptake may be a significant

prognostic factor for overall survival in addition to cervical lymph node

metastasis in oral cavity cancer. J. Surg. Oncol. 2014 110:702-706. (c) 2014

Wiley Periodicals, Inc.
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dc.language.isoen-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Adenosquamous-
dc.subject.MESHCarcinoma, Squamous Cell-
dc.subject.MESHContrast Media-
dc.subject.MESHFluorodeoxyglucose F18-
dc.subject.MESHHumans-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMouth Neoplasms-
dc.subject.MESHMultimodal Imaging-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHPositron-Emission Tomography-
dc.subject.MESHPrognosis-
dc.subject.MESHRadiopharmaceuticals-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTomography, Spiral Computed-
dc.titlePrognostic significance of the intratumoral heterogeneity of (18) F-FDG uptake in oral cavity cancer.-
dc.typeArticle-
dc.identifier.pmid24975131-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/jso.23703/abstract;jsessionid=5158D57934B26CF11366992729314E88.f04t02-
dc.contributor.affiliatedAuthor윤, 준기-
dc.contributor.affiliatedAuthor안, 영실-
dc.contributor.affiliatedAuthor신, 유섭-
dc.contributor.affiliatedAuthor김, 철호-
dc.contributor.affiliatedAuthor이, 수진-
dc.type.localJournal Papers-
dc.identifier.doi10.1002/jso.23703-
dc.citation.titleJournal of surgical oncology-
dc.citation.volume110-
dc.citation.number6-
dc.citation.date2014-
dc.citation.startPage702-
dc.citation.endPage706-
dc.identifier.bibliographicCitationJournal of surgical oncology, 110(6). : 702-706, 2014-
dc.identifier.eissn1096-9098-
dc.relation.journalidJ000224790-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Nuclear Medicine & Molecular Imaging
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
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