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Reduction of allergenicity of irradiated ovalbumin in ovalbumin-allergic mice.

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dc.contributor.authorSeo, JH-
dc.contributor.authorLee, JW-
dc.contributor.authorKim, JH-
dc.contributor.authorByun, EB-
dc.contributor.authorLee, SY-
dc.contributor.authorKang, IJ-
dc.contributor.authorByun, MW-
dc.date.accessioned2011-01-26T05:51:17Z-
dc.date.available2011-01-26T05:51:17Z-
dc.date.issued2007-
dc.identifier.issn0969-806X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/1302-
dc.description.abstractEgg allergy is one of the most serious of the immediate hypersensitivity reactions to foods. Such an allergic disorder is mediated by IgE antibodies stimulated by T-helper type 2 (Th2) lymphocytes. This study was undertaken to evaluate changes of allergenicity and cytokine profiles by exposure of irradiated ovalbumin (OVA), a major allergen of egg white, in the OVA-allergic mice model. OVA solutions (2 mg/ml in 0.01 M phosphate buffered saline (PBS) were gamma-irradiated to 50 and 100 kGy. The allergenicity in the OVA-allergy-induced mice model was remarkably reduced when challenged with irradiated OVA. Cultures of spleen cells harvested from OVA-sensitized mice showed a significant decrease in Th2 cytokine levels of ILs-4 and -5 with a concomitant increase in Th1 cytokine levels of IL-12 when co-cultured with irradiated OVA. However, IFN-γ level decreased dependant on the radiation dose of co-cultured OVA. The levels of IgEs and Th2-cytokine were reduced dependant on the radiation dose. These data show that the irradiated OVA could downregulate the activity of Th2 lymphocytes in OVA-sensitized mice.-
dc.language.isoen-
dc.titleReduction of allergenicity of irradiated ovalbumin in ovalbumin-allergic mice.-
dc.typeArticle-
dc.contributor.affiliatedAuthor이, 수영-
dc.type.localJournal Papers-
dc.citation.titleRadiation physics and chemistry (Oxford, England : 1993)-
dc.citation.volume76-
dc.citation.number11-12-
dc.citation.date2007-
dc.citation.startPage1855-
dc.citation.endPage1857-
dc.identifier.bibliographicCitationRadiation physics and chemistry (Oxford, England : 1993), 76(11-12). : 1855-1857, 2007-
dc.relation.journalidJ00969806X-
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Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
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