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Blood Neutrophil-to-Lymphocyte Ratio predicts tumor recurrence in patients with hepatocellular carcinoma within Milan criteria after hepatectomy

Authors
호, 석광
Department
대학원 의학과
Degree
Doctor (2016)
Table Of Contents
Ⅰ. INTRODUCTION 1

Ⅱ. METHODS 3

A. Patients’ inclusion criterioa and characteristics 3

B. Follow-up strategy, recurrence and treatment pattern 4

C. To determined the optimal cutoff of continuous variavles 5

D. Statistical Analysis 10

Ⅲ. RESULTS 11

A. Survival outcomes 11

B. Prognositic facrors of tumor recurrence in HCC Patients within Milan criteria 14

C. Prognositic facrors of early recurrence in HCC patients within Milan criteria 17

Ⅳ. DISCUSSION 18

Ⅴ. CONCLUSION 23

REFERENCES 24
Abstract
Purpose: The systemic inflammation biomarker, Neutrophil-to-Lymphocyte Ratio (NLR), has been reported as one of the adverse prognostic factors for HCC patient. The purpose of this study was to evaluate whether NLR could predict the risk of recurrence and death for the HCC patient confirming to Milan criteria after hepatectomy.

Methods: Retrospective analysis was performed on a database of HCC patients who underwent hepatectomy between March 2001 and December 2011. The cutoff value of NLR was decided by receiver operating characteristic (ROC) curve analysis. Univariate and multivariate regression analysis were performed to identify predictive factors of recurrence and death.

Results: A total of 213 patients were included in the present study. The median follow-up period was 48 months. One hundred and seven patients were experienced tumor recurrence; forty of them were recurred within 12 months (early recurrence). NLR≥1.505, albumin≤3.75g/dl, microvascular invasion and high grade of cirrhosis were found to be independent factors for adverse recurrence-free survival in multivariate regression analysis. And NLR≥1.945 was also found as a prognosis factor for early recurrence by univariate regression analysis.

Conclusions: Elevated preoperative NLR can be easily obtained and reliable biomarker for assessing the tumor recurrence and early recurrence of Milan criteria HCC after the initial hepatectomy.
Keywords
Neutrophilslymphocytesprognosishepatocellular carcinomahepatectomy
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Theses > School of Medicine / Graduate School of Medicine > Doctor
AJOU Authors
호, 석광
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