Association of Lamivudine-Resistant Mutational Patterns with the Antiviral Effect of Adefovir in Patients with Chronic Hepatitis B

Abstract

"ABSTRACT ⅰ

TABLE OF CONTENTS ⅱ

LIST OF TABLES iii

ABBREVIATION iv

I. INTRODUCTION 1

II. MATERIALS AND METHODS 3

A. Patients 3

B. Blood tests 3

C. Detection of mutations by restriction fragment mass polymorphism (RFMP)

Analysis 5

D. Sequencing analysis 6

E. Definition 6

F. Statistical analysis 7

III.RESULTS 8

A. Virologic and biochemical response to adefovir 8

B. Antiviral efficacy of Adefovir between the HBeAg-positive and -negative

Groups 8

C. Baseline hepatitis B virus polymerase mutations 8

D. Effect of lamivudine-resistant mutational pattern on the virologic and

biochemical response to adefovir 12

IV. DISCUSSION 15

V. CONCLUSION 18

REFERENCES 19

국문요약 24

"