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Association of Lamivudine-Resistant Mutational Patterns with the Antiviral Effect of Adefovir in Patients with Chronic Hepatitis B

차, 충근
Doctor (2009)
"ABSTRACT ⅰ TABLE OF CONTENTS ⅱ LIST OF TABLES iii ABBREVIATION iv I. INTRODUCTION 1 II. MATERIALS AND METHODS 3 A. Patients 3 B. Blood tests 3 C. Detection of mutations by restriction fragment mass polymorphism (RFMP) Analysis 5 D. Sequencing analysis 6 E. Definition 6 F. Statistical analysis 7 III.RESULTS 8 A. Virologic and biochemical response to adefovir 8 B. Antiviral efficacy of Adefovir between the HBeAg-positive and -negative Groups 8 C. Baseline hepatitis B virus polymerase mutations 8 D. Effect of lamivudine-resistant mutational pattern on the virologic and biochemical response to adefovir 12 IV. DISCUSSION 15 V. CONCLUSION 18 REFERENCES 19 국문요약 24 "
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