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Early recanalization after intravenous administration of recombinant tissue plasminogen activator as assessed by pre- and post-thrombolytic angiography in acute ischemic stroke patients.

Authors
Lee, KY; Han, SW; Kim, SH; Nam, HS; Ahn, SW; Kim, DJ; Seo, SH; Kim, DI; Heo, JH
Citation
Stroke, 38(1):192-193, 2007
Journal Title
Stroke
ISSN
0039-24991524-4628
Abstract
BACKGROUND AND PURPOSE: Recanalization rates after the intravenous (IV) recombinant tissue plasminogen activator (rt-PA) treatment have been poorly studied in acute stroke.



METHODS: CT angiography was performed before IV rt-PA in all patients and digital subtraction angiography was undertaken for intra-arterial thrombolysis in cases of no improvement after rt-PA infusion.



RESULTS: Forty-five patients were treated with IV rt-PA. Initial CT angiography showed relevant arterial occlusions in 35 patients. Recanalization after rt-PA therapy was demonstrated by digital subtraction angiography in 7 of the 31 patients with the occlusion on initial CT angiography: 2/16 in the internal carotid or proximal middle cerebral artery, 3/11 in the distal middle cerebral artery and 2/4 in the basilar artery occlusion.



CONCLUSIONS: The early recanalization rate after IV rt-PA use was very low in cases with large proximal arterial occlusions. CT angiography before IV rt-PA may be useful for the prediction of its efficacy.
MeSH terms
Angiography, Digital Subtraction/methodsAngiography, Digital Subtraction/standardsBrain Ischemia/drug therapy*Brain Ischemia/physiopathologyBrain Ischemia/radiographyCerebral Angiography/methods*Cerebral Angiography/standardsCerebral Arteries/drug effects*Cerebral Arteries/physiopathologyCerebral Arteries/radiography*Fibrinolytic Agents/administration & dosageHumansPredictive Value of TestsPreoperative Care/methodsPreoperative Care/standardsRecombinant Fusion Proteins/administration & dosageRetrospective StudiesStroke/drug therapy*Stroke/physiopathologyStroke/radiographyTime FactorsTissue Plasminogen Activator/administration & dosage*Tomography, X-Ray Computed/methodsTomography, X-Ray Computed/standardsTreatment Outcome
DOI
10.1161/01.STR.0000251788.03914.00
PMID
17110611
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
AJOU Authors
남, 효석
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